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IRF6 — NLRP3
Text-mined interactions from Literome
Schroder et al., Immunobiology 2012
:
Previous work has attributed this phenomenon ( known as LPS ` priming ' ) to
LPS dependent
induction of
NLRP3 expression
Liao et al., Inflamm Res 2013
:
LPS induced
NLRP3 protein expression was regulated through the NADPH oxidase/ROS/NF-?B dependent, JAK2/PI3-kinase/AKT/NF-?B dependent, and MAPK dependent pathways, while ATP induced caspase-1 activation was regulated through the NADPH oxidase/ROS dependent pathway
Hernandez-Cuellar et al., J Immunol 2012
:
In this study, we found that endogenous NO is involved in the
regulation of
NLRP3 inflammasome activation by either IFN-ß pretreatment or long-term
LPS stimulation
Pontillo et al., Reprod Sci 2013
:
In CTBs and DSCs,
LPS induced an augmented expression of CASP1 and IL1B and the specific upregulation of
NLRP3 within the 3 NLRs tested
Mao et al., Drug Alcohol Depend 2013
:
However, there was only a 2.7-fold increase in
NLRP3 expression in
response to
LPS in the morphine-tolerant rats compared to a 4.5-fold increase in the placebo-control animals ... Our data indicate that, in the morphine-tolerant state,
LPS induced expression of
NLRP3 is suppressed and cytokine/chemokine expression is inhibited, which may be one of the mechanisms involved in morphine induced immunosuppression