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IL8 — TLR2

Text-mined interactions from Literome

Sugawara et al., Infect Immun 2001 : PGP induced a high level of interleukin-8 production at doses of 100 ng/ml and higher in OCT treated THP-1 cells compared with Salmonella LPS, and the production was significantly inhibited by anti-CD14 and anti-TLR2 but not anti-TLR4 antibodies
Re et al., J Biol Chem 2001 : TLR2 stimulation also resulted in preferential induction of IL-8 and p19/IL-23
Dziarski et al., J Endotoxin Res 2000 : Therefore, TLR2 is a functional receptor for both Gram positive and Gram negative bacteria and it induces activation of IL-8
Uehara et al., J Med Microbiol 2002 : Anti-TLR2 and anti-TLR4 monoclonal antibodies ( MAbs ) inhibited the IL-8 production induced by PGN and LTA as well as LPS, respectively, in IFN-gamma primed oral epithelial cells, whereas neither MAb inhibited IL-8 production induced by MDP
Matsumura et al., Immunology 2003 : TRAF6-NF-kappaB pathway is essential for interleukin-1 induced TLR2 expression and its functional response to TLR2 ligand in murine hepatocytes
Sabroe et al., J Immunol 2003 : Activation of either TLR2 or TLR4 caused changes in adhesion molecule expression, respiratory burst ( alone, and synergistically with fMLP ), and IL-8 generation, which was, in part, dependent upon p38 mitogen activated protein kinase signaling
Pivarcsi et al., Int Immunol 2003 : The microbial compound induced increase in IL-8 gene expression could be inhibited by anti-TLR2 and anti-TLR4 neutralizing antibodies, suggesting that TLRs are involved in the pathogen induced expression of this pro-inflammatory cytokine
Oshikawa et al., Biochem Biophys Res Commun 2003 (Lung Diseases) : The results demonstrated three patterns of gene expression : the TLR2 and myeloid differentiation factor 88 ( MyD88 ) gene expressions were induced in AM in response to lipopolysaccharide (LPS), interleukin (IL)-1beta , or tumor necrosis factor-alpha or in the lung tissue of an LPS induced acute lung injury model ; the gene expressions of TLR1, -3, -6, CD14, and MD2 were unchanged ; and the TLR4 and TLR5 gene expressions were downregulated in AM following inflammatory stimuli
Latz et al., J Immunol 2004 : We found that OMPC and Hib-OMPC engaged human Toll-like receptor 2 (TLR2) expressed in human embryonic kidney (HEK) cells, inducing IL-8 production, and engaged mouse TLR2 on bone marrow derived dendritic cells, inducing TNF release
Soong et al., J Clin Invest 2004 : Ligation of either TLR2 or asialoGM1 by ligands with specificity for either receptor, by Pseudomonas aeruginosa, or by Staphylococcus aureus stimulates IL-8 production through activation of NF-kappa B, as mediated by TLR2 and MyD88
Moore et al., J Antimicrob Chemother 2004 : Lag phase S. pneumoniae treated at sub-MIC ( 1/8 MIC ) cefotaxime or faropenem induced 11-fold and 8-fold increases, respectively, in TLR2 mediated IL-8 promoter activity when compared with untreated bacteria
Becker et al., Toxicol Appl Pharmacol 2005 : When NHBE were stimulated with PM ( 2.5-10 ), PM2.5, and UF PM, in the presence or absence of inhibitors of TLR2 and TLR4 activation, a blocking antibody to TLR2 inhibited production of IL-8 , while TLR4 antagonist E5531 or the LPS inhibitor Polymixin B had no effect
Hajishengallis et al., Infect Immun 2005 : Induction of interleukin-1beta (IL-1beta), IL-6, IL-8 , or tumor necrosis factor alpha in human THP-1 cells by LT-IIaB or LT-IIbB was inhibited by anti-TLR2 but not by anti-TLR4 antibody
Torok et al., Infect Immun 2005 : Secretion of IL-8 from H. pylori infected HEK293 cells was augmented by the expression of TLR2 or TLR5
Köllisch et al., Immunology 2005 : The TLR ligands peptidoglycan, Pam3Cys and flagellin which bind to TLR2, TLR1/TLR2 heterodimer, and TLR5, respectively, also induced IL-8 secretion, whereas no IL-8 was induced by LPS, R-848, loxoribine and cytosine guanine dinucleotide containing oligodeoxynucleotide
Ding et al., Helicobacter 2005 (Helicobacter Infections) : We have previously shown that H. pylori induced NF-(kappa)B activation and interleukin (IL)-8 secretion are mediated by Toll-like receptor (TLR) 2 in epithelial cells
Raffatellu et al., Infect Immun 2005 : Collectively, these data suggest that the scarcity of neutrophils in intestinal infiltrates of typhoid fever patients is due to a capsule mediated reduction of TLR dependent IL-8 production in the intestinal mucosa
Maldonado-Bernal et al., Parasite Immunol 2005 : The interaction of LPPG with TLR2 and TLR4 resulted in activation of NF-kappaB and release of interleukin (IL)-10, IL-12p40, tumour necrosis factor (TNF)-alpha, and IL-8 from human monocytes
Takeyama et al., Prostate 2006 (Inflammation) : Transient transfection of the dominant negative mutant TLR2 ( P681H ) into PC-3 cells attenuated M. hominis induced IL-8 secretion and NF-kappaB activation
Hung et al., Nephrol Dial Transplant 2006 : The LMPS enhanced the secretion of CCL2/MCP-1 and CXCL8/interleukin-8 (CXCL8/IL-8) in TLR-defective human embryonic kidney (HEK) 293 cells only when transfected with a TLR2 expressing plasmid
Kramer et al., J Leukoc Biol 2006 (Crohn Disease) : Moreover, they lack MDP induced enhancement of TLR mediated tumor necrosis factor alpha, interleukin (IL)-12 , and IL-10 production, which is observed in control DC with intact NOD2
Seyberth et al., J Med Chem 2006 : Lipolanthionine peptides act as inhibitors of TLR2 mediated IL-8 secretion ... A collection of analytically defined lipolanthionine peptide amides exhibited an inhibitory effect of the TLR2 mediated IL-8 secretion when applied in high molar excess to the agonistic synthetic lipopeptide Pam3Cys-Ser- ( Lys ) 4-OH
Mueller et al., J Immunol 2006 : TLR4/MD-2 mediated LPS uptake and TLR ligand induced I-kappaBalpha phosphorylation and IL-8 secretion were significantly diminished in Th2 cytokine primed IECs
Tachado et al., J Leukoc Biol 2007 : These studies demonstrate that Pc-mediated IL-8 release by human AM requires the coexpression of MR and TLR2 and further supports the concept that combinatorial interactions of macrophage innate receptors provide specificity of host defense cell responses to infectious challenge
Gao et al., Zhonghua Yan Ke Za Zhi 2006 : The activity of IkappaBalpha in THCE cells was decreased to 10.31 +/- 1.30 ( gray scale value ) and 8.15 +/- 2.37 at 30 min after challenged with AF mycelium or supernatant extract agent compared to 51.57 +/- 5.58 and 49.23 +/- 3.49 of control group ( P < 0.01 ), and was reverted at 2 h. The secretion of IL-8 and TNF-alpha was partly inhibited by blocking TLR2 or TLR4 ( P < 0.05 ), obviously inhibited by blocking TLR2 and TLR4 ( 50 % and 40 % compared to that of control group ) ( P < 0.01 ) when challenged with AF mycelium. And that was markedly inhibited by blocking TLR4 or blocking TLR2 and TLR4 when challenged with AF supernatant ( P < 0.01 ). The secretion of IL-8 and TNF-alpha was not inhibited by blocking TLR2 when challenged with AF supernatant ( P > 0.05 )
Kuroishi et al., Mol Immunol 2007 : Human parotid saliva contains soluble toll-like receptor (TLR) 2 and modulates TLR2 mediated interleukin-8 production by monocytic cells
Flacher et al., J Immunol 2006 : TLR2 and TLR3 ligands increase IL-6 and IL-8 production, while dsRNA alone stimulates TNF-alpha release
Cho et al., Immunol Lett 2007 (Arthritis, Rheumatoid) : Thus, TLR-2 activation in RA FLS by microbial constituents could be involved in the induction of VEGF and IL-8 and thereby promote inflammation either directly or via angiogenesis
Uehara et al., Mol Immunol 2007 : Anti-RP3 Abs markedly promoted the release of IL-8 induced by chemically synthesized TLR and NOD ligands mimicking bacterial components : TLR2-agonistic lipopeptide ( FSL-1 ), TLR3-agonistic poly I:C, TLR4-agonistic lipid A ( LA-15-PP ), TLR7/8-agonistic single stranded RNA ( ssPolyU ), TLR9-agonistic bacterial CpG DNA, NOD1-agonistic FK156/565 and NOD2-agonistic muramyldipeptide ( MDP ) in THP-1 cells and human peripheral blood mononuclear cells, although sole incubation with anti-PR3 Abs induced only a low level of IL-8
Kanczkowski et al., Horm Metab Res 2007 (Adrenal Cortex Neoplasms) : The aim of this study was to clarify the role of different TLR ligands in IL8 production in NCI-H295R cells
Yokota et al., FEMS Immunol Med Microbiol 2007 (Inflammation) : Weak IL-8 induction by H. pylori LPS preparations was suppressed by expression of a dominant negative mutant of TLR2 but not of TLR4
Onishi et al., Infect Immun 2008 : We provide direct evidence for BspA binding to TLR2 and demonstrate that the release of the chemokine interleukin-8 from human gingival epithelial cells by BspA is TLR2 dependent
Koff et al., Am J Physiol Lung Cell Mol Physiol 2008 : We conclude that multiple TLR ligands induce airway epithelial cell production of IL-8 and VEGF via a Duox1 -- > ROS -- > TACE -- > TGF-alpha -- > EGFR phosphorylation pathway
Buchholz et al., Infect Immun 2008 (Inflammation) : IL-8 induced at 30 h postinfection by C. trachomatis was dependent on NOD1 signaling through RIP2 ; however, the IL-8 response was independent of MyD88 dependent TLR signaling
Wang et al., Blood 2008 : We and others have reported that Toll-like receptor ( TLR ) proteins are present on human neutrophils and that granulocyte-macrophage colony stimulating factor ( GM-CSF ) treatment enhances IL-8 ( CXCL8 ) secretion in response to stimulation with TLR ligands
Sadik et al., Int J Biochem Cell Biol 2008 (Lyme Disease) : Systematic analysis highlights the key role of TLR2/NF-kappaB/MAP kinase signaling for IL-8 induction by macrophage-like THP-1 cells under influence of Borrelia burgdorferi lysates
Farhat et al., Vet Immunol Immunopathol 2008 (Mastitis, Bovine...) : TLR2 dependent induction of IL-8 release was stronger in medium containing human serum albumin than in medium containing fetal calf serum
Kuo et al., J Am Soc Nephrol 2008 (Ischemia...) : Furthermore, experiments with toll-like receptor 4 (TLR-4)-and TLR-2-deficient mice demonstrated that uric acid induced exocytosis of Weibel-Palade bodies is mediated by TLR-4 and that uric acid induced release of IL-8 requires both TLR-2 and TLR-4
Berndt et al., Equine Vet J 2009 (Airway Obstruction...) : In human airway epithelium, TLR2 activation leads to interleukin (IL)-8 production
Mahanonda et al., J Periodontal Res 2009 : Stimulation of HGECs with highly purified TLR2 , 3 or 5 ligands led to expression of hBD-2 and of IL-8
Noronha et al., J Leukoc Biol 2009 (Inflammatory Bowel Diseases) : In contrast, B cells from UC patients express TLR2 but generally do not demonstrate spontaneous IL-8 secretion ; however, significant IL-8 production is inducible via TLR2 stimulation
Choi et al., Atherosclerosis 2010 : GSA increased IL-8 transcription via promoter activation and enhanced CXCL8 release from VSMCs. GSA induced promoter activation of the IL-8 gene was suppressed by dominant negative mutants of TLR-4, MyD88, and TRIF, but not by a dominant negative form of TLR-2
Ben Yebdri et al., Eur J Immunol 2009 : Altogether, these results show that extracellular nucleotides, via P2Y(2) and P2Y(6) receptors, regulate neutrophil migration by controlling TLR2 induced IL-8 release from human monocytes
Lee et al., J Parasitol 2010 : We also performed reverse transcriptase-polymerase chain reaction ( RT-PCR ) and flow cytometry to determine whether TLR and MUC expression is regulated by interferon (IFN)-gamma, interleukin-4 , or monoclonal antibodies ( mAbs ) against G. seoi 46 kDa antigen
Im et al., Mol Immunol 2009 : Collectively, these results suggest that flagellin induced IL-8 expression requires formation of lipid rafts, intracellular TLR activation, and subsequent activation of PKC and MAP kinases leading to the activation of the transcription factors NF-kappaB and NF-IL6 in human alveolar type II epithelial cells
Suzuki et al., J Dent Res 2009 (Gingival Overgrowth) : In human gingival fibroblasts, cyclosporin alone did not induce evident inflammatory responses, but augmented the expression of CD54 and the production of interleukin (IL)-6 and IL-8 induced by TLR ligands, whereas phenytoin attenuated those responses
Manuse et al., Virology 2010 : Unexpectedly, TLR3 activation in infected cells led to enhanced IL-8 secretion, which correlated with increased RIG-I expression
Khan et al., J Immunol 2010 : Conversely, stable overexpression of Sigirr diminished NF-kappaB mediated IL-8 responses to TLR ligands
Acorci-Valério et al., Scand J Immunol 2010 (Paracoccidioidomycosis) : Interestingly, IL-8 and IL-10 production involved TLR2 and mainly TLR4 modulation
Han et al., Vet Microbiol 2010 : Involvement of TLR21 in baculovirus induced interleukin-12 gene expression in avian macrophage-like cell line HD11
Rajaram et al., J Immunol 2010 : The induced IL-8 response mediated by mannose capped lipoarabinomannan and the mannose receptor is independent of TLR2 and NF-kappaB activation
Piconi et al., AIDS 2010 (HIV Infections) : Activated T cells ( Ki67 ( + ) ), Treg lymphocytes ( CD4 ( + ) /CD25high/Foxp3+ ), divided into naive and activated cells based on PD1 expression, interleukin (IL)-10 and transforming growth factor ( TGF ) -beta production, annexin V, activation of caspases 8 and 9, Toll-like receptor (TLR)2 and TLR4 expression on immune cells, and plasma lipopolysaccharide (LPS) concentration were analyzed ... Activated T cells ( Ki67 ( + ) ), Treg lymphocytes ( CD4 ( + ) /CD25high/Foxp3+ ), divided into naive and activated cells based on PD1 expression, interleukin (IL)-10 and transforming growth factor ( TGF ) -beta production, annexin V, activation of caspases 8 and 9, Toll-like receptor (TLR)2 and TLR4 expression on immune cells, and plasma lipopolysaccharide (LPS) concentration were analyzed
Chung et al., J Infect Dis 2010 (Hepatitis C, Chronic) : Alloantigen presentation by monocytes isolated from HCV infected patients results in impaired production of interleukin 17 by naive CD4 ( + ) T cells in the presence of TLR ligands
Li et al., Cardiovascular diabetology 2010 : Stimulation of TLR2 or TLR4 induced NF-?B activation, and the expression of ICAM-1, IL-6 and IL-8
Li et al., Int J Mol Med 2011 : In addition, Atg7 gene expression silencingled to down-regulation of TLR mediated IL-8 expression in IECs, which indicates a potential role of autophagy in generating innate-immune responses
Nischalke et al., Int J Cancer 2012 (Carcinoma, Hepatocellular...) : Finally, in carriers of the TLR2 -196 to -174 del allele, stimulation of monocytes resulted in significantly lower TLR2 expression levels and interleukin-8 (IL-8) induction than in individuals with the TLR2 -196 to -174 ins/ins genotype ( p < 0.05 )
Thornton et al., Neonatology 2012 : Toll-like receptor 1/2 stimulation induces elevated interleukin-8 secretion in polymorphonuclear leukocytes isolated from preterm and term newborn infants
Zheng et al., Journal of Cancer 2011 : The increase in IL-8 expression was dependent on Toll-like receptor 2 and NF?B
Wilhelmsen et al., Innate Immun 2012 (Sepsis) : We found that TLR2 activation specifically induces the expression of the genes IL-6, IL-8 , CSF2, CSF3, ICAM1 and SELE by human umbilical vein ECs and human lung microvascular ECs
Davidson et al., PloS one 2011 : Both interleukin-8 (IL-8) and human ß-defensin 2 ( HßD2 ) are expressed by respiratory epithelial cells in response to toll-like receptor 2 (TLR2) receptor stimulation
Hanamsagar et al., Trends Immunol 2012 : TLR signaling triggers the transcriptional activation of pro-interleukin-1ß ( pro-IL-1ß ) and pro-IL-18 that are processed into their active forms by the inflammasome
Larcombe et al., PloS one 2012 : In contrast, after vitamin D supplementation TLR2/1L induced responses e.g. IL-1ß, IL-8 and IL-12 were significantly reduced in the Dené MDMs
Som et al., Clinical and vaccine immunology : CVI 2012 (Disease Models, Animal...) : Anti-inflammatory SMAMPs prevented the induction of tumor necrosis factor (TNF), interleukin 6 (IL-6), and IL-10 in response to S. aureus or LTA, but no other TLR2 ligands
Miura et al., Hepatology 2013 (Fatty Liver...) : Here we show that both TLR2 and palmitic acid are required for activation of the inflammasome, interleukin (IL)-1a , and IL-1ß, resulting in the progression of NASH
Li et al., eLife 2012 : A sequence containing 13 nucleotides near the active site of 23S rRNA ribozyme, which catalyzes peptide bond synthesis, was both necessary and sufficient to trigger TLR13 dependent interleukin-1ß production
Massari et al., Infect Immun 2013 (Chlamydia Infections) : Using MOMP formed in pure protein micelles ( proteosomes ), we show the induction of TLR2 dependent interleukin-8 (IL-8) and IL-6 secretion in vitro, the involvement of TLR1 as a TLR2 coreceptor, and the activation of both NF-?B and mitogen activated protein ( MAP ) kinase intracellular pathways
Koblansky et al., Immunity 2013 (Genetic Predisposition to Disease...) : Toll-like receptor 11 ( TLR11 ) recognizes T. gondii profilin ( TgPRF ) and is required for interleukin-12 production and induction of immune responses that limit cyst burden in Toxoplasma gondii infected mice
Schamber-Reis et al., J Biol Chem 2013 (Disease Resistance...) : Altogether, our results indicate the redundant and essential role of nucleic acid sensing TLR3, TLR7 and TLR9 in inducing interleukin 12, development of a T1 response, and resistance to L. major infection in resistant C57BL/6 mice
Wu et al., PloS one 2013 : We showed that the hADSCs expressed Toll-like Receptors (TLR) 1, TLR2 , TLR3, TLR4, and TLR6 and that lipopolysaccharide (LPS) significantly induced the production of pro-inflammatory cytokines ( Cyclooxygenase-2 (Cox-2), Interleukin-1ß (IL-1ß), Interleukin-6 (IL-6), and Interleukin-8 (IL-8) )
Herath et al., PloS one 2013 (MAP Kinase Signaling System) : METHODOLOGYPRINCIPAL FINDINGS : This study systematically investigated the effects of P. gingivalis LPS1435/1449 and LPS1690 on the expression of TLR2 and TLR4 signal transduction and the activation of pro-inflammatory cytokines IL-6 and IL-8 in human gingival fibroblasts ( HGFs )