Ayroldi et al., Mol Cell Biol 2002
(MAP Kinase Signaling System) :
In fact, GILZ overexpression inhibits TCR activated NF-kappaB nuclear translocation, interleukin-2 production, FasL upregulation, and the consequent activation induced apoptosis
Beaulieu et al., Arthritis Rheum 2010
(Arthritis, Experimental) :
GILZ was highly expressed in the synovium of patients with active RA and in cultured RA synovial fibroblasts, and GILZ overexpression in synovial fibroblasts inhibited IL-6 and IL-8 release