◀ Back to KRAS
HIF1A — KRAS
Text-mined interactions from Literome
Mori et al., Mol Cancer Res 2009
(Pancreatic Neoplasms) :
In conclusion, overexpression of KLF5 in human pancreatic cancer cells is not mediated by
KRAS/Raf/MAPK/Erk signaling, but
involves the IL-1beta/IL-1R system, p38, and the transcription factor
HIF-1alpha
Kikuchi et al., Cancer Res 2009
(Anoxia...) :
Many hypoxic responses are mediated by hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha, and we sought to define the
roles of mutant
KRAS and BRAF in the induction of
HIF-1alpha and HIF-2alpha in colon cancer cells ... Ectopic expression of mutant
K-ras in Caco2 cells
enhanced the hypoxic induction of only
HIF-1alpha , whereas mutant BRAF enhanced both HIF-1alpha and HIF-2alpha ... Our data reveal that oncogenic
KRAS and BRAF mutations differentially
regulate the hypoxic induction of
HIF-1alpha and HIF-2alpha in colon cancer, and this may potentially contribute to the phenotypic differences of KRAS and BRAF mutations in colon tumors