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MAP3K8 — NFKB1

Pathways - manually collected, often from reviews:

• KEGG Toll-like receptor signaling pathway: MAP3K8 → NFKB1 (protein-protein, inhibition)
• Reactome Reaction: NFKB1 → MAP3K8 (reaction) Beinke et al., Mol Cell Biol 2003*, Lang et al., Mol Cell Biol 2004*, Belich et al., Nature 1999*
• Reactome Reaction: NFKB1 → MAP3K8 (direct_complex) Beinke et al., Mol Cell Biol 2003*, Lang et al., Mol Cell Biol 2004*, Belich et al., Nature 1999*
• WikiPathways Structural Pathway of Interleukin 1 (IL-1): NFKB1 → MAP3K8 (activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: Complex of MAP3K8-TNIP2-NFKB1-NFKB2-NFKB2-RELA Bouwmeester et al., Nat Cell Biol 2004
• IRef Bind Interaction: Complex of 16 proteins Bouwmeester et al., Nat Cell Biol 2004
• IRef Biogrid Interaction: NFKB1 — MAP3K8 (physical association, affinity chromatography technology) Belich et al., Nature 1999*
• IRef Biogrid Interaction: NFKB1 — MAP3K8 (physical association, affinity chromatography technology) Eliopoulos et al., J Biol Chem 2006
• IRef Biogrid Interaction: NFKB1 — MAP3K8 (direct interaction, two hybrid) Wang et al., Molecular systems biology 2011
• IRef Biogrid Interaction: NFKB1 — MAP3K8 (physical association, affinity chromatography technology) Bouwmeester et al., Nat Cell Biol 2004
• IRef Biogrid Interaction: NFKB1 — MAP3K8 (physical association, affinity chromatography technology) Lang et al., Mol Cell Biol 2004*
• IRef Biogrid Interaction: NFKB1 — MAP3K8 (direct interaction, pull down) Belich et al., Nature 1999*
• IRef Biogrid Interaction: NFKB1 — MAP3K8 (direct interaction, two hybrid) Belich et al., Nature 1999*
• MIPS CORUM TNF-alpha/Nf-kappa B signaling complex (RPL6, RPL30, RPS13, CHUK, DDX3X, NFKB2, NFKBIB, REL, IKBKG, NFKB1, MAP3K8, RELB, GLG1, NFKBIA, RELA, TNIP2, GTF2I): TNF-alpha/Nf-kappa B signaling complex (RPL6, RPL30, RPS13, CHUK, DDX3X, NFKB2, NFKBIB, REL, IKBKG, NFKB1, MAP3K8, RELB, GLG1, NFKBIA, RELA, TNIP2, GTF2I) complex (CHUK-DDX3X-GLG1-GTF2I-IKBKG-MAP3K8-NFKB1-NFKB2-NFKBIA-NFKBIB-REL-RELA-RELB-RPL30-RPL6-RPS13-TNIP2) Bouwmeester et al., Nat Cell Biol 2004
• MIPS CORUM ABIN2-NFKB1-MAP3K8 complex: ABIN2-NFKB1-MAP3K8 complex complex (MAP3K8-NFKB1-TNIP2) Lang et al., Mol Cell Biol 2004*
• IRef Corum Interaction: Complex of 18 proteins (association, tandem affinity purification) Bouwmeester et al., Nat Cell Biol 2004
• IRef Dip Interaction: NFKB1 — MAP3K8 (physical association, tandem affinity purification) Bouwmeester et al., Nat Cell Biol 2004
• IRef Hprd Interaction: NFKB1 — MAP3K8 (two hybrid) Eliopoulos et al., J Biol Chem 2006, Belich et al., Nature 1999*
• IRef Hprd Interaction: NFKB1 — MAP3K8 (in vitro) Eliopoulos et al., J Biol Chem 2006, Belich et al., Nature 1999*
• IRef Hprd Interaction: NFKB1 — MAP3K8 (in vivo) Eliopoulos et al., J Biol Chem 2006, Belich et al., Nature 1999*
• IRef Hprd Interaction: Complex of 290 proteins (in vivo) Bouwmeester et al., Nat Cell Biol 2004
• IRef Intact Interaction: NFKB1 — MAP3K8 (physical association, tandem affinity purification) Bouwmeester et al., Nat Cell Biol 2004
• IRef Intact Interaction: NFKB1 — MAP3K8 (physical association, two hybrid) Wang et al., Molecular systems biology 2011
• IRef Intact Interaction: Complex of NFKB1-MAP3K8-TNIP2-NFKB2 (association, anti bait coimmunoprecipitation) Lang et al., Mol Cell Biol 2004*
• IRef Intact Interaction: Complex of 13 proteins (association, anti bait coimmunoprecipitation) Lang et al., Mol Cell Biol 2004*
• IRef Ophid Interaction: NFKB1 — MAP3K8 (aggregation, confirmational text mining) Belich et al., Nature 1999*
• IRef Ophid Interaction: NFKB1 — MAP3K8 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Eliopoulos et al., J Virol 2002 (Carcinoma...) : The oncogenic protein kinase Tpl-2/Cot contributes to Epstein-Barr virus encoded latent infection membrane protein 1-induced NF-kappaB signaling downstream of TRAF2 ... Consistent with this observation, catalytically inactive Tpl-2 also blocked CD40 mediated NF-kappaB activation, which largely depends on TRAF2
Kane et al., Mol Cell Biol 2002 : Akt dependent phosphorylation specifically regulates Cot induction of NF-kappa B-dependent transcription ... The regulation of NF-kappa B-dependent transcription by Cot requires Akt dependent phosphorylation of serine 400 ( S400 ), near the carboxy terminus of Cot
Das et al., J Biol Chem 2005 : Activated Tpl2 phosphorylates MKK4/SEK1 upstream of JNK and stimulates NF-kappaB DNA binding and transcriptional activity by mechanisms that are independent of the nuclear translocation of p50 and p65
Neumann et al., Biol Chem 2006 : Furthermore, we show that mitogen activated protein kinase kinase kinases ( MAP3K ), like TPL2 ( tumour progression locus 2 ) and transforming growth factor beta activated kinase 1 ( TAK1 ), have no impact on H. pylori induced activation of NF-kappaB
Chikamatsu et al., Mol Immunol 2007 : This finding gives a new insight into the role of Cot in the FcvarepsilonRI mediated NF-kappaB activation in mast cells
Gohda et al., Biochem Biophys Res Commun 2007 : These results strongly suggest that unlike cytokine signaling, Tax induced NFkappaB activation does not involve K63 polyubiquitination mediated MAP3K activation
Cismasiu et al., Biochem J 2009 : The implied involvement of Cot kinase in BCL11B mediated NF-kappaB activation in response to TCR activation is supported by the fact that a Cot kinase dominant negative mutant or Cot kinase siRNA ( small interfering RNA ) knockdown blocked BCL11B mediated NF-kappaB activation
Lee et al., Cancer Res 2009 : Furthermore, inhibition of Tpl2 reduced the arsenite induced promoter activity of NF-kappaB and activator protein-1 (AP-1), indicating that NF-kappaB and AP-1 are downstream transducers of arsenite triggered Tpl2