◀ Back to TLR2
TLR1 — TLR2
Pathways - manually collected, often from reviews:
-
KEGG Toll-like receptor signaling pathway:
TLR1
→
TLR2
(protein-protein, binding/association)
-
KEGG Tuberculosis:
HSPA9
→
Complex of TLR1-TLR2-TLR6
(protein-protein, activation)
-
KEGG Tuberculosis:
Complex of TLR1-TLR2-TLR6
→
MYD88
(protein-protein, activation)
-
NCI Pathway Database Endogenous TLR signaling:
TLR1 (TLR1)
→
SAA1/TLR2/TLR1 complex (TLR2-TLR1-SAA1)
(modification, collaborate)
Cheng et al., J Immunol 2008*, He et al., Blood 2009*
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Endogenous TLR signaling:
TLR1 (TLR1)
→
TLR2 (TLR2)
(modification, collaborate)
Cheng et al., J Immunol 2008*, He et al., Blood 2009*
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Endogenous TLR signaling:
SAA1/TLR2/TLR1 complex (TLR2-TLR1-SAA1)
→
SAA1 (SAA1)
(modification, collaborate)
Cheng et al., J Immunol 2008*, He et al., Blood 2009*
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Endogenous TLR signaling:
SAA1/TLR2/TLR1 complex (TLR2-TLR1-SAA1)
→
TLR2 (TLR2)
(modification, collaborate)
Cheng et al., J Immunol 2008*, He et al., Blood 2009*
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Endogenous TLR signaling:
TLR1 (TLR1)
→
HMGB1/TLR2/TLR1 complex (TLR2-TLR1-HMGB1)
(modification, collaborate)
Park et al., Am J Physiol Cell Physiol 2006, Yu et al., Shock 2006
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Endogenous TLR signaling:
TLR1 (TLR1)
→
TLR2 (TLR2)
(modification, collaborate)
Park et al., Am J Physiol Cell Physiol 2006, Yu et al., Shock 2006
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Endogenous TLR signaling:
HMGB1 (HMGB1)
→
HMGB1/TLR2/TLR1 complex (TLR2-TLR1-HMGB1)
(modification, collaborate)
Park et al., Am J Physiol Cell Physiol 2006, Yu et al., Shock 2006
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Endogenous TLR signaling:
HMGB1/TLR2/TLR1 complex (TLR2-TLR1-HMGB1)
→
TLR2 (TLR2)
(modification, collaborate)
Park et al., Am J Physiol Cell Physiol 2006, Yu et al., Shock 2006
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Endogenous TLR signaling:
BGN/TLR2/TLR1/MD2 (dimer)/MYD88/TIRAP complex (TLR2-TLR1-LY96-BGN-MYD88-TIRAP)
→
MYD88/TIRAP complex (MYD88-TIRAP)
(modification, collaborate)
Schaefer et al., J Clin Invest 2005
Evidence: mutant phenotype
-
NCI Pathway Database Endogenous TLR signaling:
BGN/TLR2/TLR1/MD2 (dimer)/MYD88/TIRAP complex (TLR2-TLR1-LY96-BGN-MYD88-TIRAP)
→
BGN/TLR2/TLR1/MD2 (dimer) complex (TLR2-TLR1-LY96-BGN)
(modification, collaborate)
Schaefer et al., J Clin Invest 2005
Evidence: mutant phenotype
-
NCI Pathway Database Endogenous TLR signaling:
MYD88/TIRAP complex (MYD88-TIRAP)
→
BGN/TLR2/TLR1/MD2 (dimer) complex (TLR2-TLR1-LY96-BGN)
(modification, collaborate)
Schaefer et al., J Clin Invest 2005
Evidence: mutant phenotype
-
NCI Pathway Database Endogenous TLR signaling:
TLR1 (TLR1)
→
TLR2 (TLR2)
(modification, collaborate)
Zanin-Zhorov et al., FASEB J 2003*
Evidence: mutant phenotype
-
NCI Pathway Database Endogenous TLR signaling:
TLR1 (TLR1)
→
HSP60/TLR2/TLR1 complex (TLR2-TLR1-HSPD1)
(modification, collaborate)
Zanin-Zhorov et al., FASEB J 2003*
Evidence: mutant phenotype
-
NCI Pathway Database Endogenous TLR signaling:
TLR2 (TLR2)
→
HSP60/TLR2/TLR1 complex (TLR2-TLR1-HSPD1)
(modification, collaborate)
Zanin-Zhorov et al., FASEB J 2003*
Evidence: mutant phenotype
-
NCI Pathway Database Endogenous TLR signaling:
HSP60/TLR2/TLR1 complex (TLR2-TLR1-HSPD1)
→
HSP60 (HSPD1)
(modification, collaborate)
Zanin-Zhorov et al., FASEB J 2003*
Evidence: mutant phenotype
-
NCI Pathway Database Endogenous TLR signaling:
IRAK2 (IRAK2)
→
HMGB1/TLR2/TLR1/MYD88/TIRAP complex (TLR2-TLR1-HMGB1-MYD88-TIRAP)
(modification, collaborate)
Park et al., J Biol Chem 2004
Evidence: mutant phenotype, other species
-
NCI Pathway Database Endogenous TLR signaling:
IRAK2 (IRAK2)
→
HMGB1/TLR2/TLR1/MYD88/TIRAP/IRAK/IRAK2/IRAK4 complex (TLR2-TLR1-HMGB1-IRAK1-IRAK2-IRAK4-MYD88-TIRAP)
(modification, collaborate)
Park et al., J Biol Chem 2004
Evidence: mutant phenotype, other species
-
NCI Pathway Database Endogenous TLR signaling:
IRAK4 (IRAK4)
→
HMGB1/TLR2/TLR1/MYD88/TIRAP complex (TLR2-TLR1-HMGB1-MYD88-TIRAP)
(modification, collaborate)
Park et al., J Biol Chem 2004
Evidence: mutant phenotype, other species
-
NCI Pathway Database Endogenous TLR signaling:
IRAK4 (IRAK4)
→
HMGB1/TLR2/TLR1/MYD88/TIRAP/IRAK/IRAK2/IRAK4 complex (TLR2-TLR1-HMGB1-IRAK1-IRAK2-IRAK4-MYD88-TIRAP)
(modification, collaborate)
Park et al., J Biol Chem 2004
Evidence: mutant phenotype, other species
-
NCI Pathway Database Endogenous TLR signaling:
IRAK (IRAK1)
→
HMGB1/TLR2/TLR1/MYD88/TIRAP complex (TLR2-TLR1-HMGB1-MYD88-TIRAP)
(modification, collaborate)
Park et al., J Biol Chem 2004
Evidence: mutant phenotype, other species
-
NCI Pathway Database Endogenous TLR signaling:
IRAK (IRAK1)
→
HMGB1/TLR2/TLR1/MYD88/TIRAP/IRAK/IRAK2/IRAK4 complex (TLR2-TLR1-HMGB1-IRAK1-IRAK2-IRAK4-MYD88-TIRAP)
(modification, collaborate)
Park et al., J Biol Chem 2004
Evidence: mutant phenotype, other species
-
NCI Pathway Database Endogenous TLR signaling:
HMGB1/TLR2/TLR1/MYD88/TIRAP complex (TLR2-TLR1-HMGB1-MYD88-TIRAP)
→
HMGB1/TLR2/TLR1/MYD88/TIRAP/IRAK/IRAK2/IRAK4 complex (TLR2-TLR1-HMGB1-IRAK1-IRAK2-IRAK4-MYD88-TIRAP)
(modification, collaborate)
Park et al., J Biol Chem 2004
Evidence: mutant phenotype, other species
-
NCI Pathway Database Endogenous TLR signaling:
CD14 (CD14)
→
BGN/TLR2/TLR1/MD2 (dimer) complex (TLR2-TLR1-LY96-BGN)
(modification, activates)
Schaefer et al., J Clin Invest 2005
Evidence: physical interaction
-
NCI Pathway Database Endogenous TLR signaling:
BGN (BGN)
→
BGN/TLR2/TLR1/MD2 (dimer) complex (TLR2-TLR1-LY96-BGN)
(modification, collaborate)
Schaefer et al., J Clin Invest 2005
Evidence: physical interaction
-
NCI Pathway Database Endogenous TLR signaling:
TLR2/MD2 complex (LY96-TLR2)
→
TLR1/MD2 complex (LY96-TLR1)
(modification, collaborate)
Schaefer et al., J Clin Invest 2005
Evidence: physical interaction
-
NCI Pathway Database Endogenous TLR signaling:
TLR2/MD2 complex (LY96-TLR2)
→
BGN/TLR2/TLR1/MD2 (dimer) complex (TLR2-TLR1-LY96-BGN)
(modification, collaborate)
Schaefer et al., J Clin Invest 2005
Evidence: physical interaction
-
NCI Pathway Database Endogenous TLR signaling:
TLR1/MD2 complex (LY96-TLR1)
→
BGN/TLR2/TLR1/MD2 (dimer) complex (TLR2-TLR1-LY96-BGN)
(modification, collaborate)
Schaefer et al., J Clin Invest 2005
Evidence: physical interaction
-
NCI Pathway Database Endogenous TLR signaling:
SFTPA1 (SFTPA1)
→
SFTPA1/TLR2/TLR1 complex (TLR2-TLR1-SFTPA1)
(modification, collaborate)
Murakami et al., J Biol Chem 2002*, Sato et al., J Immunol 2003*
Evidence: physical interaction
-
NCI Pathway Database Endogenous TLR signaling:
TLR1 (TLR1)
→
TLR2 (TLR2)
(modification, collaborate)
Murakami et al., J Biol Chem 2002*, Sato et al., J Immunol 2003*
Evidence: physical interaction
-
NCI Pathway Database Endogenous TLR signaling:
TLR1 (TLR1)
→
SFTPA1/TLR2/TLR1 complex (TLR2-TLR1-SFTPA1)
(modification, collaborate)
Murakami et al., J Biol Chem 2002*, Sato et al., J Immunol 2003*
Evidence: physical interaction
-
NCI Pathway Database Endogenous TLR signaling:
TLR2 (TLR2)
→
SFTPA1/TLR2/TLR1 complex (TLR2-TLR1-SFTPA1)
(modification, collaborate)
Murakami et al., J Biol Chem 2002*, Sato et al., J Immunol 2003*
Evidence: physical interaction
-
NCI Pathway Database Endogenous TLR signaling:
TLR6 (TLR6)
→
VCAN/TLR2/TLR1 complex (TLR2-TLR1-VCAN)
(modification, collaborate)
Kim et al., Nature 2009
Evidence: physical interaction
-
NCI Pathway Database Endogenous TLR signaling:
VCAN (VCAN)
→
VCAN/TLR2/TLR1 complex (TLR2-TLR1-VCAN)
(modification, collaborate)
Kim et al., Nature 2009
Evidence: physical interaction
-
NCI Pathway Database Endogenous TLR signaling:
CD14 (CD14)
→
VCAN/TLR2/TLR1 complex (TLR2-TLR1-VCAN)
(modification, activates)
Kim et al., Nature 2009
Evidence: physical interaction
-
NCI Pathway Database Endogenous TLR signaling:
VCAN/TLR2/TLR1 complex (TLR2-TLR1-VCAN)
→
TLR2 (TLR2)
(modification, collaborate)
Kim et al., Nature 2009
Evidence: physical interaction
-
NCI Pathway Database Endogenous TLR signaling:
HMGB1/TLR2/TLR1 complex (TLR2-TLR1-HMGB1)
→
MYD88/TIRAP complex (MYD88-TIRAP)
(modification, collaborate)
Yu et al., Shock 2006
Evidence: mutant phenotype
-
NCI Pathway Database Endogenous TLR signaling:
HMGB1/TLR2/TLR1 complex (TLR2-TLR1-HMGB1)
→
HMGB1/TLR2/TLR1/MYD88/TIRAP complex (TLR2-TLR1-HMGB1-MYD88-TIRAP)
(modification, collaborate)
Yu et al., Shock 2006
Evidence: mutant phenotype
-
NCI Pathway Database Endogenous TLR signaling:
MYD88/TIRAP complex (MYD88-TIRAP)
→
HMGB1/TLR2/TLR1/MYD88/TIRAP complex (TLR2-TLR1-HMGB1-MYD88-TIRAP)
(modification, collaborate)
Yu et al., Shock 2006
Evidence: mutant phenotype
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Krutzik et al., Nat Med 2003
(Leprosy) :
In addition, interferon (IFN)-gamma and granulocyte-macrophage colony stimulating factor ( GM-CSF )
enhanced TLR1 expression in monocytes and dendritic cells, respectively, whereas IL-4 downregulated
TLR2 expression
Oshikawa et al., Biochem Biophys Res Commun 2003
(Lung Diseases) :
The results demonstrated three patterns of gene expression : the
TLR2 and myeloid differentiation factor 88 ( MyD88 ) gene expressions were
induced in AM in response to lipopolysaccharide (LPS), interleukin (IL)-1beta, or tumor necrosis factor-alpha or in the lung tissue of an LPS induced acute lung injury model ; the gene expressions of
TLR1 , -3, -6, CD14, and MD2 were unchanged ; and the TLR4 and TLR5 gene expressions were downregulated in AM following inflammatory stimuli
Massari et al., J Immunol 2006
:
Together, these data provide new evidence that
TLR2 recognizes PorB through direct binding, and that PorB induced cell activation is
mediated by a
TLR2/TLR1 complex
Wu et al., Int J Immunogenet 2008
:
As an important member of TLRs,
TLR1 is
involved in the recognition of triacylated lipoproteins and mycobacterial products by binding to
TLR2 to form a heterodimer ... As an important member of TLRs,
TLR1 is
involved in the recognition of triacylated lipoproteins and mycobacterial products by binding to
TLR2 to form a heterodimer
Aravalli et al., Journal of neuroinflammation 2008
(Histoplasmosis) :
Furthermore, Yps3p induced
TLR2 signaling was
suppressed by vaccinia virus encoded
TLR inhibitors
Regueiro et al., Infect Immun 2009
:
We showed that Klebsiella induced
TLR2 and TLR4 upregulation was
dependent on
TLR activation
So et al., Glia 2009
(Cardiovirus Infections) :
More importantly,
TLR3 was
required for TMEV induced early
TLR2 upregulation in primary astrocytes leading to the production of TLR2 dependent cytokines such as IL-6
Chamorro et al., J Immunol 2009
:
TLR triggering on tolerogenic dendritic cells
results in
TLR2 up-regulation and a reduced proinflammatory immune program
Bayas et al., Clin Exp Immunol 2009
(Bacterial Infections...) :
In peripheral blood mononuclear cells,
TLR-9 stimulation with type A CpG ODN
resulted in a higher expression of
TLR-1 , -2, -4, -5 and -8 in MS patients ( n = 7 ) compared with healthy controls ( n = 11 )
Messlik et al., J Proteome Res 2009
(Chronic Disease...) :
The aim of this study was to characterize the
role of
TLR2 or TLR4 deficiency in epithelial cell stress responses under noninflamed and inflamed conditions using TLR-deficient mice and
TLR ( -/- ) cross bred IL-10-deficient mice as a model for genetically driven experimental colitis
Goethals et al., Glia 2010
(Wallerian Degeneration) :
Upon axotomy,
TLR1 becomes strongly
induced , while most other
TLR expression levels remain unaffected
Yang et al., Bing Du Xue Bao 2011
(Marek Disease...) :
By comparing the TLRs transcription between YL040920 and CVI988/Rispens infected microglia, it was suggested that vvMDV YL040920 might
induce more
TLR15 transcript than the attenuated vaccine strain CVI988/Rispens ( P < or = 0.01/0.001 ), while CVI988/Rispens induced more
TLR1LB transcript than YL040920 ( P < or = 0.001 )
Stridh et al., Journal of neuroinflammation 2011
(Hypoxia-Ischemia, Brain) :
In contrast,
TLR-2 was constitutively expressed in the brain and
TLR-2 deficiency
reduced HI injury
Kim et al., FEMS Microbiol Lett 2012
(Inflammation) :
L. plantarum genomic DNA mediated inhibition of signaling pathway and tumor necrosis factor-alpha was accompanied by the suppression of
toll-like receptor (TLR) 2 , TLR4, and TLR9 and the induction of interleukin-1 receptor associated kinase M, a negative
regulator of
TLR
Jia et al., Shanghai Kou Qiang Yi Xue 2011
:
CD14,
TLR4 receptors are involved in P.e-LPS effect and CD14,
TLR2 and TLR4 receptors are
involved in P.g-LPS effect in mouse osteoblast
Kumar et al., PloS one 2012
(Infection...) :
Moreover, stimulation of the Muller glia with
TLR 2 , 3, 4, 5, 7 and 9 agonists
resulted in an increased
TLR expression as assayed by Western blot and flow cytometry
Wang et al., PloS one 2012
(Cell Transformation, Neoplastic...) :
TLR2 : TLR6 complexes
mediate the effect of NF-?B inactivation by CDA-2
Feriotti et al., PloS one 2013
(Disease Susceptibility...) :
Mannan or P. brasiliensis
induced decreased expression of MR and
TLR2 on A/J macrophages, whereas CR3,
TLR4 and TLR2 were reduced on B10.A cells