UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

◀ Back to NOTCH1

CREBBP — NOTCH1

Pathways - manually collected, often from reviews:

Reactome Reaction: CREBBP → NOTCH1 (reaction) Fryer et al., Genes Dev 2002, Wallberg et al., Mol Cell Biol 2002, Fryer et al., Mol Cell 2004, Nam et al., Cell 2006
Reactome Reaction: CREBBP → NOTCH1 (indirect_complex) Fryer et al., Genes Dev 2002, Wallberg et al., Mol Cell Biol 2002, Nam et al., Cell 2006
Reactome Reaction: CREBBP → NOTCH1 (direct_complex)

Text-mined interactions from Literome

Chen et al., Basic Clin Pharmacol Toxicol 2007 (Leukemia) : Curcumin, both histone deacetylase and p300/CBP-specific inhibitor, represses the activity of nuclear factor kappa B and Notch 1 in Raji cells
Fu et al., J Biol Chem 2009 : This is the first evidence that Notch activation affects R-Smad expression and that cooperative induction of histone acetylation at specific promoters underlies the selective synergy between Notch and TGFbeta signaling pathways