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FGFR1 — MMP2
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Rachagani et al., Carcinogenesis 2012
(Neoplasm Invasiveness...) :
The downregulation of
FGFR1 in turn
led to downregulation of pAkt, pERK1/2, pNF-?B, pIkBa, uPA,
MMP-9 , vimentin, N-cadherin, Twist, Slug and Zeb1 and upregulation of E-cadherin, Occludin, Cytokeratin-18 and Caspase-9 in MUC4 knockdown BXPC3 and Capan1 cells compared with scramble vector transfected cells
Levi et al., Proc Natl Acad Sci U S A 1996
:
These studies demonstrate that
FGFR1 may be a specific
target for
MMP2 on the cell surface, yielding a soluble FGF receptor that may modulate the mitogenic and angiogenic activities of FGF