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MMP2 — NOX1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Luchtefeld et al., Biochem Biophys Res Commun 2005
(Cardiomyopathies...) :
Since reactive oxygen species ( ROS ) induce MMP-2 and angiotensin II (ANG II) enhances NADPH-oxidase dependent ROS formation, we assessed whether ANG II induces
MMP-2 in a
NADPH-oxidase dependent manner
Li et al., Diabetes 2005
:
Overall, these results demonstrate that leptin
induced HASMC proliferation and
MMP-2 expression through a PKC dependent activation of
NAD ( P ) H oxidase with subsequent activation of the ERK1/2/NF-kappaB pathways and that therapeutic metformin concentrations effectively inhibit these biological effects
Spallarossa et al., Cardiovasc Res 2006
(MAP Kinase Signaling System) :
Inhibition of
NAD ( P ) H oxidase attenuates the increase in
MMP-2 , but augments the doxorubicin induced increase in MMP-9
Cook-Mills et al., Cell Mol Biol Incl Cyto Enzymol 2006
:
The endothelial cell NADPH oxidase and endothelial cell
MMP activities are
required for VCAM-1 dependent lymphocyte migration as determined by scavenging of ROS, by pharmacologic or antisense inhibition of
NADPH oxidase and by pharmacologic inhibition of endothelial cell MMPs
Liu et al., J Invest Dermatol 2012
(Melanoma...) :
Matrix metalloproteinase-2 (MMP-2) was
increased by
Nox1 overexpression at the mRNA, protein, and activity levels, and decreased by Nox1 knockdown