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CASP3 — IFI27
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Rosato et al., Mol Cancer Ther 2002
(Leukemia) :
FP also blocked SB-related p21WAF1-CIP1 induction through a caspase independent mechanism and triggered the
caspase mediated cleavage of
p27KIP1 and retinoblastoma protein
Maggio et al., Cancer Res 2004
(Leukemia) :
It was also accompanied by the
caspase dependent down-regulation of
p27 ( KIP1 ), cyclins A, E, and D ( 1 ), and cleavage and diminished phosphorylation of retinoblastoma protein
Pei et al., Clin Cancer Res 2004
(Multiple Myeloma) :
These events were associated with nuclear factor kappaB inactivation, c-Jun NH ( 2 ) -terminal kinase activation, p53 induction, and
caspase dependent cleavage of p21 ( CIP1 ),
p27 ( KIP1 ), and Bcl-2, as well as Mcl-1, X-linked inhibitor of apoptosis, and cyclin D1 down-regulation
Akashiba et al., J Neurochem 2006
:
In this study, we demonstrate that reductions of both
p27 and neuronal viability were
dependent on activity of calpain, a Ca ( 2+ ) -dependent protease, but not on activity of
caspase 3
Zheng et al., Cancer Chemother Pharmacol 2007
(Melanoma) :
Molecular studies indicated that WP760 induced p53 stabilization, checkpoint kinase 2 and
p27 ( Kip1 ) protein upregulation, and
activation of
caspase-3
Wu et al., Planta Med 2007
:
The mechanisms underlying these pharmacological effects include reduced expression of cell cycle mediators such as CDK4, cyclins D1 and A, retinoblastoma ( Rb ) and vascular endothelial growth factor receptor 1 ( VEGFR-1 ), and promotion of
caspase mediated
activation of CDK inhibitors p21(Cip1) and
p27 ( Kip )
Krämer et al., Oncogene 2008
(Melanoma) :
This correlates with the HU-induced degradation of the cyclin dependent kinase inhibitors ( CDKI ) p21 and
p27 ,
mediated by the proteasome or
caspase-3
Wang et al., J Int Med Res 2008
:
Carnosic acid also augmented these effects when induced by a low ( physiological ) concentration of arsenic trioxide, which was associated with upregulation of
p27 and
activation of
caspase-9
Nakamura et al., Invest New Drugs 2010
(Leukemia...) :
TMPP treatment effected a reduction in both cell cycle progression signals ( FoxM1, KIS, Cdc25B, Cyclin D1, Cyclin A, and Aurora-B ) and tumor cell survival (
p27 ( Kip1 ) and p21 ( Cip1 ) ), as well as
induced the activation of
caspase-3 and -9