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IL12B — IL6
Text-mined interactions from Literome
Harley et al., Clin Diagn Lab Immunol 1999
(Chronic Disease...) :
Expression of IL-2, IL-10,
IL-12 ( p35 and p40 ), and IFN-gamma was
detected in most nondiseased biopsies, while
IL-6 was detected in a minority, and IL-4 and IL-5 were both undetectable
Willermain et al., Invest Ophthalmol Vis Sci 2000
:
Although interferongamma enhanced
IL-6 and IL-8 production, CD40 triggering of IFNgamma activated hRPE cells did not
induce IL-12 secretion
Kawashima et al., Arthritis Rheum 2003
(Arthritis, Rheumatoid) :
IL-1 beta and, less effectively,
IL-12 could
induce RA fibroblast-like synoviocytes to produce
IL-6 , but IL-18 failed to have an effect
Yasukawa et al., Nat Immunol 2003
:
In macrophages lacking the Socs3 gene or carrying a mutation of the SOCS3 binding site in gp130, the lipopolysaccharide induced production of tumor necrosis factor (TNF) and
IL-12 is
suppressed by both IL-10 and
IL-6
Hessle et al., Inflammation 2003
(Inflammation) :
We have seen that Gram-positives preferentially
induce IL-12 and TNF-alpha, whereas Gram-negatives induce more IL-10,
IL-6 , and IL-8
Ross et al., Infect Immun 2004
:
CyaA significantly augmented LPS induced
IL-6 and IL-10 and
inhibited LPS-driven tumor necrosis factor alpha and
IL-12p70 production from bone marrow derived DC and macrophages
Conant et al., J Immunol 2004
(Disease Models, Animal...) :
The activated T cells produced the proinflammatory cytokine, IFN-gamma in
response to
IL-12 , and
IL-6 was secreted in response to CpG oligonucleotide
Cuéllar et al., Biomedica 2004
:
The dendritic cells pre exposed to single doses of endotoxin demonstrated a reduced capacity to mature, reduced CD83 expression,
inhibited secretion of
IL-12 , TNFalpha, IL-10 and diminished secretion of
IL-6
Jenkins et al., Int Immunol 2005
:
Finally, we show that glycan components of 0-3hRP are required for optimal cytokine production since protease treatment of 0-3hRP had no effect on
IL-12p40 production and only a slight
effect on
IL-6 , while sodium meta-periodate treatment almost completely abolished production of both cytokines
Fuss et al., Inflamm Bowel Dis 2006
(Crohn Disease) :
Finally, we found that
IL-23 induced T cell production of IL-17 and
IL-6 are also greatly reduced after antibody treatment
Reeve et al., Photochem Photobiol 2006
(Dermatitis, Contact...) :
UVA enhanced radiation also upregulated the expression of cutaneous IFN-gamma and
IL-12 and
inhibited expression of both
IL-6 and IL-10, compared with the activity of SSUV
Wei et al., Biochimie 2006
:
Promutoxin is also able to stimulate the release of
IL-12 , TNFalpha, IL-6 and IL-1beta from human monocytes, and
induce IL-2, TNFalpha and
IL-6 release from T cells, indicating that this snake venom group IIA PLA(2) is actively involved in the inflammatory process in man caused by snake venom poisoning
Zhou et al., Nat Immunol 2007
:
T helper cells that produce interleukin 17 ( IL-17 ; ` T ( H ) -17 cells ' ) are a distinct subset of proinflammatory cells whose in vivo function requires
IL-23 but whose in vitro differentiation
requires only
IL-6 and transforming growth factor-beta ( TGF-beta )
Dar et al., Vet Immunol Immunopathol 2008
:
In contrast, in LNC, only
IL-12 was stimulated by all three classes of CpG ODNs, while IFNalpha, and
IL-6 were
induced by A- and C-class ODNs
Rachitskaya et al., J Immunol 2008
:
Th17 cells
require IL-6 and TGFbeta for lineage commitment and
IL-23 for maintenance
Cheung et al., J Immunol 2008
(Inflammation) :
IL-17A, IL-17F, and
IL-23 could
induce the release of chemokines GRO-alpha/CXCL1, IL-8/CXCL8, and MIP-1beta/CCL4 from eosinophils, while IL-17F and IL-23 could also increase the production of proinflammatory cytokines IL-1beta and
IL-6
Enríquez-de-Salamanca et al., Cytokine 2008
(Conjunctivitis, Allergic...) :
TNF-alpha stimulated secretion of
IL-12p40 was significantly
increased by 30 min ; GM-CSF, MCP-1,
IL-6 , IL-7, IL-8, and RANTES were significantly increased by 2 h, and IFN-gamma and IL-1alpha by 24 h
Barkman et al., Microbes Infect 2008
:
Intact bifidobacteria
induced massive production of
IL-12 ( 1 ng/ml ) and IL-6 ( > 30 ng/ml ) from human PBMC, whereas fragmented bifidobacteria induced
IL-6 , but no IL-12
Annunziato et al., Blood 2009
(Autoimmune Diseases) :
While murine Th17 cells develop in response to
IL-6 , IL-1, and transforming growth factor ( TGF ) -beta, human Th17 cells originate from these CD161 ( + ) precursors in
response to IL-1beta and
IL-23 , the need for TGF-beta being controversial
Morishima et al., Biochem Biophys Res Commun 2009
:
TGF-beta and
IL-6 induce Th17 differentiation, and
IL-23 is
required for expansion and maintenance of Th17 cells
Martner et al., Infect Immun 2009
:
If pneumococcal LytA was inactivated by mutation or by culture in a medium containing excess choline, the pneumococci
induced production of significantly more TNF, IFN-gamma, and
IL-12 in PBMC, whereas the production of
IL-6 , IL-8, and IL-10 was unaffected ... Further, adding autolyzed pneumococci to intact bacteria inhibited production of TNF, IFN-gamma, and
IL-12 in a dose dependent manner but did not
inhibit production of
IL-6 , IL-8, and IL-10 in response to the intact bacteria
Radstake et al., PloS one 2009
(Disease Progression...) :
In line with these observation, circulating levels of IL-17
inducing cytokines
IL-6 ,
IL-23 and IL-1alpha were increased in all or subsets of SSc patients
Nold-Petry et al., J Biol Chem 2009
(MAP Kinase Signaling System) :
In addition, we silenced IL-18Ralpha with small interfering RNA in primary human blood cells and observed up to 4-fold increases in the secretion of lipopolysaccharide- and
IL-12/IL-18 induced IL-1beta,
IL-6 , interferon-gamma, and CD40L
Lin et al., J Neurochem 2009
:
Using highly enriched cultures of neonatal murine microglia we show that
IL-6 alone has direct effects on microglia as it activates STAT3 and extracellular signal regulated kinase pathways in a time- and dose dependent fashion and it
enhances interferon-gamma (IFNgamma) stimulated
IL-12 secretion
Kato et al., Glycoconj J 2010
:
Engagement of SIGNR1 on PEMs with an anti-SIGNR1-specific rat IgM antibody, ERTR9,
induced production of
IL-12 and tumor necrosis factor (TNF)-alpha from PEMs, while secretion of
IL-6 and IL-1beta was not detected with the same treatment
Myer et al., Exp Gerontol 2010
:
There were relatively minor age related changes in TGF-ß and
IL-6 which promote Th17 differentiation, but
IL-23 , a Th17-suvival cytokine,
increased more than 40-fold across the lifespan
Scott et al., Am J Reprod Immunol 2011
(Disease Models, Animal...) :
Increased expression of IL-6 and
IL-12p35 and decreased expression of IL-10 occurred in FIV infected tissues at early pregnancy ; at late gestation,
IL-6 expression
increased and IL-1ß and SDF-1a decreased
Donini et al., Prostate 2012
(Prostatic Neoplasms) :
LNCaP
enhance IL-1ß, IL-23,
IL-6 , and TNF-a secretion by decreasing glucan dependent NADPH oxidase activity, whereas glucan increases
IL-12 production through NADPH oxidase unrelated mechanisms
Novitskiy et al., Cancer Discov 2011
(Breast Neoplasms...) :
During polyoma middle T ( PyMT ) induced tumor progression, levels of Th17 inducing cytokines TGF-ß,
IL-6 ,
IL-23 were
increased in PyMT/Tgfbr2 ( KO ) tumors, which was associated with an increased number of Th17 cells
Feriotti et al., PloS one 2013
(Disease Susceptibility...) :
Importantly, both mannan and P. brasiliensis
induced the production of
IL-12 by B10.A macrophages, whereas TGF-ß, TNF-a and
IL-6 were produced by A/J cells
Carow et al., PLoS Pathog 2013
:
Instead, SOCS3 expression in infected macrophages and DCs prevented the
IL-6 mediated inhibition of TNF and
IL-12 secretion and contributed to a timely CD4+ cell dependent IFN-? expression in vivo
Salkowski et al., J Immunol 1995
:
In the spleen,
IL-6 and TNF-alpha were
induced by 30 min after LPS challenge, while increases in IL-10 and
IL-12 ( p40 ) were delayed in onset
Hegde et al., Cell Immunol 1995
(Neoplasms, Experimental) :
AK-5 tumor
induced expression of
interleukin-12 : role of
IL-12 in NK-mediated AK-5 regression
Mori et al., Int J Cancer 1996
(Body Weight...) :
IL-12 reduced the serum levels of
IL-6 , a cachexia mediator in this model, and alleviated the body weight loss and other abnormalities associated with cachexia, such as adipose tissue wasting and hypoglycemia ... These results indicate that the anticachectic activity of
IL-12 is T-cell dependent and
results from at least 2 mechanisms, the down-regulation of
IL-6 and the up-regulation of IFN-gamma
Hedges et al., Cytokine 1996
:
IL-4, IL-13, IFN-gamma, and TGF-beta 1, but not IL-2, IL-5, IL-10 or
IL-12 ,
stimulated IL-6 secretion ... IL-5,
IL-12 , IL-13 and TGF-beta 1 additively
enhanced the bacterially induced
IL-6 secretion, but they did not affect IL-8 secretion
Ruzek et al., J Exp Med 1997
(Herpesviridae Infections) :
The
IL-12 p40, IFN-gamma, TNF, and
IL-6 responses were dramatic with peak levels reaching > 150-10,000 pg/ml at 32-40 h after infection and rapidly declining thereafter
Spencer et al., Int Immunol 1997
:
A role for IL-12 in the aging process was suggested when it was found that recombinant
IL-12 ( rIL-12 ) directly stimulated splenic CD5+ B cells to secrete IL-10, and both CD5+ and CD5- B cells could be directly
induced to produce
IL-6 in response to rIL-12
Diab et al., Clin Immunol Immunopathol 1997
(Meningitis, Haemophilus) :
At this time point, strong expression of
IL-6 and TGF-beta was
detected in the brain, and also of IL-10 at 48 hr while IFN-gamma and
IL-12 were expressed at very low levels throughout the observation time
Belkaid et al., Eur J Immunol 1998
(Inflammation...) :
Infection of inflammatory macrophages in vitro using metacyclic promastigotes produced identical effects on cytokine responses regardless of whether cells from genetically resistant or susceptible mouse strains were used : IL-12 was not produced in response to infection itself, virtually every infected cell lost its ability to produce
IL-12 in response to IFN-gamma/LPS, and the
IL-6 response was partially
inhibited , while the TNF-alpha response of infected cells was unimpaired
Bromuro et al., Infect Immun 1998
(Candidiasis) :
Inoculation of CaHsp70 preparations into immunized mice induced rapid production of
interleukin-6 (IL-6) and tumor necrosis factor alpha, peaking at 2 to 5 h and declining within 24 h. CaHsp70 and CaHsp70-Cter also
induced gamma interferon ( IFN-gamma ),
IL-12 , and IL-10 but not IL-4 production by CD4+ lymphocytes cocultured with splenic accessory cells from nonimmunized mice