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APOB — MMP9

Text-mined interactions from Literome

Xu et al., Circulation 1999 : Because oxidized LDL ( ox-LDL ) is implicated in many proatherogenic events, we hypothesized that ox-LDL would regulate expression of MMP-9 and tissue inhibitor of metalloproteinase-1 ( TIMP-1 ) in monocyte derived macrophages ... Ox-LDL induced increase in MMP-9 expression was abrogated by HDL ( 100 microg/mL ) ... n-LDL had no significant effect on MMP-9 or TIMP-1 expression ... CONCLUSIONS : These data demonstrate that unlike n-LDL, ox-LDL upregulates MMP-9 expression while reducing TIMP-1 expression in monocyte derived macrophages ... Furthermore, HDL abrogates ox-LDL induced MMP-9 expression
Ardans et al., J Leukoc Biol 2002 : ox-LDL, LDL , and HDL alone had no effect on MMP-1, MMP-9 , or TIMP-1 production ... However, in the presence of tumor necrosis factor (TNF)-alpha and GM-CSF, ox-LDL enhanced MMP-1 significantly by two- to threefold, increased MMP-9 slightly, and had no effect on TIMP-1 production
Kume et al., Nihon rinsho. Japanese journal of clinical medicine 2004 (Arteriosclerosis) : Lectin-like oxidized LDL receptor-1 ( LOX-1 ) is a cell surface receptor for oxidized LDL, which is abundantly expressed in atherosclerotic plaques and is involved in oxidized LDL induced MMP production and apoptosis
May et al., Thromb Haemost 2005 (Arteriosclerosis) : We studied the effect of E-LDL on the activation of plasminogen and matrix metalloproteinases ( MMPs ) in monocytes and vascular smooth muscle cells ( VSMCs ) as well as on MMP activation during cellular interactions ... Together, enzymatical modification of LDL allows a direct activation of MMP expression in monocytes and VSMCs, and indirectly promotes the induction of paracrine, cytokine mediated intercellular activation processes