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CBL — PTPN11

Pathways - manually collected, often from reviews:

• Reactome Reaction: CBL → PTPN11 (reaction) Wong et al., Proc Natl Acad Sci U S A 2002, Fong et al., J Biol Chem 2003, Tanaka et al., Mol Cell Biol 2008*
• Reactome Reaction: CBL → PTPN11 (indirect_complex) Wong et al., Proc Natl Acad Sci U S A 2002, Tanaka et al., Mol Cell Biol 2008*

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: PTPN11 — CBL (physical association, affinity chromatography technology) Hoff et al., Eur J Immunol 2007*
• IRef Biogrid Interaction: PTPN11 — CBL (physical association, affinity chromatography technology) Chernock et al., Blood 2001
• IRef Biogrid Interaction: PTPN11 — CBL (physical association, affinity chromatography technology) Tanaka et al., Mol Cell Biol 2008*
• IRef Hprd Interaction: PTPN11 — CBL (in vivo) Chernock et al., Blood 2001
• IRef Intact Interaction: Complex of 13 proteins (association, tandem affinity purification) Brehme et al., Proc Natl Acad Sci U S A 2009
• IRef Intact Interaction: Complex of 37 proteins (association, tandem affinity purification) Brehme et al., Proc Natl Acad Sci U S A 2009

Text-mined interactions from Literome

Hakak et al., Oncogene 2000 : Since activation of Akt is dependent on PI3-kinase, this suggests that the effect of Shp-2 on Akt activation may be mediated , at least in part, by its effects on the interaction between PI3-kinase and Cbl
Tanaka et al., Mol Cell Biol 2008 : The stimulation dependent ubiquitination of gp130 was mediated by c-Cbl , an E3 ligase, which was recruited to gp130 in a tyrosine phosphorylated SHP2 dependent manner
Thien et al., Oncogene 1997 (Lymphoma, B-Cell) : Furthermore the expression of 70Z-Cbl greatly enhances EGF induced tyrosine phosphorylation of the protein tyrosine phosphatase SHP-2