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CD4 — PTPN11

Pathways - manually collected, often from reviews:

• NCI Pathway Database TCR signaling in naïve CD4+ T cells: SHP2 (PTPN11) → TCR/CD3/MHC II/CD4/LCK/ZAP-70 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-LCK-ZAP70) (modification, inhibits)
  Kwon et al., EMBO J 2005, Han et al., Science 1998, Michel et al., J Biol Chem 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database TCR signaling in naïve CD4+ T cells: SHP2 (PTPN11) → TCR/CD3/MHC II/CD4/Fyn complex (CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4-FYN-CD247) (modification, inhibits)
  Kwon et al., EMBO J 2005, da Silva et al., Proc Natl Acad Sci U S A 1997
  Evidence: mutant phenotype, physical interaction, other species
• Reactome Reaction: CD4 → PTPN11 (reaction) Carter et al., Immunol Res 2003, Sheppard et al., FEBS Lett 2004, Keir et al., Annu Rev Immunol 2008, Fife et al., Immunol Rev 2008