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EGFR — PTPN11

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: PTPN11 → Complex of EGFR-PTPN11 (directlyIncreases, EGFR/PTPN11 Activity)
  Evidence: In this paper, we present a comprehensive pathway map of EGFR signaling and other related pathways.
• NCI Pathway Database SHP2 signaling: EGFR/EGFR/EGF/EGF/GNAI1/GNAI3/GAB1 complex (EGFR-EGF-GNAI1-GNAI3-GAB1) → SHP2 (PTPN11) (translocation, activates) Yart et al., J Biol Chem 2001
  Evidence: physical interaction
• NCI Pathway Database SHP2 signaling: SHP2 (PTPN11) → EGFR/EGFR/EGF/EGF/GRB2/GAB1 complex (EGFR-EGF-GRB2-GAB1) (modification, activates)
  Zhang et al., Mol Cell Biol 2002*, Montagner et al., J Biol Chem 2005
  Evidence: mutant phenotype, assay, physical interaction, other species
• Reactome Reaction: EGFR → PTPN11 (reaction) Gual et al., Oncogene 2000, Cunnick et al., J Biol Chem 2001*, Agazie et al., Mol Cell Biol 2003, Kapoor et al., Mol Cell Biol 2004*
• Reactome Reaction: EGFR → PTPN11 (indirect_complex) Gual et al., Oncogene 2000, Cunnick et al., J Biol Chem 2001*, Agazie et al., Mol Cell Biol 2003, Kapoor et al., Mol Cell Biol 2004*

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: Complex of 168 proteins Blagoev et al., Nat Biotechnol 2003
• IRef Bind_translation Interaction: EGFR — PTPN11 (affinity chromatography technology) Schulze et al., Molecular systems biology 2005
• IRef Biogrid Interaction: PTPN11 — EGFR (physical association, affinity chromatography technology) Crovello et al., J Biol Chem 1998
• IRef Biogrid Interaction: PTPN11 — EGFR (direct interaction, unspecified method) Jones et al., Nature 2006
• IRef Biogrid Interaction: PTPN11 — EGFR (physical association, affinity chromatography technology) Schulze et al., Molecular systems biology 2005
• IRef Biogrid Interaction: PTPN11 — EGFR (physical association, affinity chromatography technology) Tomic et al., J Biol Chem 1995*
• IRef Hprd Interaction: Complex of 73 proteins (in vivo) Schulze et al., Molecular systems biology 2005
• IRef Hprd Interaction: PTPN11 — EGFR (in vitro) Held-Feindt et al., Brain Res Mol Brain Res 2001*, Agazie et al., Mol Cell Biol 2003, Schulze et al., Molecular systems biology 2005, Tomic et al., J Biol Chem 1995*
• IRef Hprd Interaction: PTPN11 — EGFR (in vivo) Held-Feindt et al., Brain Res Mol Brain Res 2001*, Agazie et al., Mol Cell Biol 2003, Schulze et al., Molecular systems biology 2005, Tomic et al., J Biol Chem 1995*
• IRef Hprd Interaction: Complex of 19 proteins (in vivo) Schulze et al., Molecular systems biology 2005
• IRef Intact Interaction: Complex of 228 proteins (association, pull down) Blagoev et al., Nat Biotechnol 2003
• IRef Intact Interaction: EGFR — PTPN11 (physical association, pull down) Schulze et al., Molecular systems biology 2005
• IRef Intact Interaction: EGFR — PTPN11 (direct interaction, protein array) Jones et al., Nature 2006
• IRef Intact Interaction: Complex of PIK3R1-EGFR-PTPN11-GAB2-GRB2 (association, anti tag coimmunoprecipitation) Brummer et al., J Biol Chem 2006*
• IRef Intact Interaction: Complex of 38 proteins (association, pull down) Blagoev et al., Nat Biotechnol 2003
• IRef Ophid Interaction: EGFR — PTPN11 (aggregation, confirmational text mining) Jones et al., Nature 2006
• IRef Ophid Interaction: EGFR — PTPN11 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Chen et al., Nat Genet 2000 (Abnormalities, Multiple...) : Our results identify the Egfr and Shp2 as components of a growth-factor signalling pathway required specifically for semilunar valvulogenesis, support the hypothesis that Shp2 is required for Egfr signalling in vivo, and provide an animal model for aortic valve disease
Wu et al., Oncogene 2000 (Brain Neoplasms...) : These data reveal a pathway that negatively regulates EGFR induced PI3-K activation in glioblastoma cells and involves interactions between SHP2 and tyrosine phosphorylated SIRPalpha1
Agazie et al., Mol Cell Biol 2003 : Molecular mechanism for a role of SHP2 in epidermal growth factor receptor signaling
Goldshmit et al., J Biol Chem 2004 : Overexpression of the phosphatase SHP-2 reduced the constitutive EGFR phosphorylation and subsequent neurite outgrowth
Rafiq et al., Circ Res 2008 : These results show that Cat.G induced cardiomyocyte apoptosis involves an increase in EGFR dependent activation of SHP2 that promotes focal adhesion kinase dephosphorylation and subsequent cardiomyocyte anoikis
Sampaio et al., Mol Cell Biol 2008 : Indeed, by up- and down-regulation of signal strength in different cell lines and through different methods, we observed that Gab1/Shp2 and Ras/ERK1-2 in concert become independent of PI3K upon strong epidermal growth factor receptor (EGFR) stimulation and dependent on PI3K upon limited EGFR activation
Zhou et al., Cell Death Differ 2008 (Breast Neoplasms...) : However, the role of SHP2 in aberrant EGFR and human EGFR2 ( HER2 ) signaling and cancer, particularly in breast cancer, has not been investigated
Furcht et al., Oncogene 2013 (Carcinoma, Non-Small-Cell Lung...) : In cells expressing EGFR mutants, which do not undergo efficient ligand mediated endocytosis, SHP2 was basally associated with GRB2 associated binder 1 (GAB1) and EGFR, and SHP2 's presence in membrane fractions was dependent on EGFR activity
Deb et al., J Biol Chem 1998 : Dominant negative forms of SHP-2 had no effect on EGF stimulated interaction of GRB2 with EGFR or SHC, nor did they influence phosphorylation of SHC and SHC/EGFR association