◀ Back to RAC1
CTNNB1 — RAC1
Pathways - manually collected, often from reviews:
-
NCI Pathway Database N-cadherin signaling events:
RAC1/GDP complex (RAC1)
→
N-cadherin/Ca2+/beta catenin-gamma catenin/alpha catenin/p120 catenin complex (CDH2-CTNNB1_JUP-CTNNA1-CTNND1)
(modification, collaborate)
Gavard et al., J Cell Sci 2004, El Sayegh et al., Mol Biol Cell 2005
Evidence: mutant phenotype, assay
-
NCI Pathway Database RAC1 signaling pathway:
E-cadherin/Ca2+/beta catenin/alpha catenin complex (CDH1-CTNNB1-CTNNA1)
→
RAC1/GTP/IQGAP1 complex (RAC1-IQGAP1)
(modification, collaborate)
Fukata et al., J Biol Chem 1999, Kuroda et al., Science 1998
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
RAC1/GTP complex (RAC1)
→
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
(translocation, activates)
Bryant et al., J Cell Sci 2007
Evidence: mutant phenotype, other species
-
NCI Pathway Database N-cadherin signaling events:
RAC1-CDC42/GDP complex (RAC1_CDC42)
→
N-cadherin/Ca2+/beta catenin-gamma catenin/alpha catenin/p120 catenin complex (CDH2-CTNNB1_JUP-CTNNA1-CTNND1)
(modification, collaborate)
Meriane et al., Mol Biol Cell 2000, Charrasse et al., J Cell Biol 2002, Comunale et al., Biol Cell 2007
Evidence: mutant phenotype, assay, other species
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
→
RAC1-CDC42/GTP/IQGAP1 complex (RAC1_CDC42-IQGAP1)
(modification, collaborate)
Fukata et al., J Biol Chem 1999, Kuroda et al., Science 1998
Evidence: physical interaction
Text-mined interactions from Literome
Fukata et al., J Biol Chem 1999
:
Cdc42 and
Rac1 regulate the interaction of IQGAP1 with
beta-catenin ... These results indicate that Cdc42 and
Rac1 negatively
regulate the IQGAP1 function by inhibiting the interaction of IQGAP1 with
beta-catenin , leading to stabilization of the cadherin-catenin complex
Fukata et al., Mol Cell Biol 2001
:
We have previously proposed that IQGAP1, an effector of Rac1 and Cdc42, negatively regulates cadherin mediated cell-cell adhesion by interacting with
beta-catenin and by causing the dissociation of alpha-catenin from cadherin-beta-catenin-alpha-catenin complexes and that activated
Rac1 and Cdc42 positively
regulate cadherin mediated cell-cell adhesion by inhibiting the interaction of IQGAP1 with beta-catenin
Noritake et al., Mol Biol Cell 2004
:
The small guanosine triphosphatase
Rac1 is activated by E-cadherin mediated cell-cell adhesion and is
required for the accumulation of actin filaments, E-cadherin, and
beta-catenin at sites of cell-cell contact ... Together, these results indicate that
Rac1 enhances the accumulation of actin filaments, E-cadherin, and
beta-catenin by acting on IQGAP1 and suggest that there exists a positive feedback loop comprised of "E-cadherin mediated cell-cell adhesion -- > Rac1 activation -- > actin-meshwork formation by IQGAP1 -- > increasing E-cadherin mediated cell-cell adhesion. ''
Esufali et al., Oncogene 2004
:
Expression of a constitutively active ( V12 )
Rac1 mutant caused up to 40-fold induction from the TOPFLASH promoter, and this was
dependent on the presence of stabilized
beta-catenin ... Furthermore, we show that Cyclin D1, an important biological Wnt target gene, is regulated by
Rac1 in a
beta-catenin/TCF dependent manner
Lyu et al., J Biol Chem 2005
:
Wnt-7a induced the accumulation of beta-catenin and the activation of Rac and
beta-catenin , and
Rac synergistically
induced the transcription of MMP-12
Ray et al., Cell Motil Cytoskeleton 2007
:
The expression of constitutively active
Rac1 ( CA-Rac1 )
restored beta-catenin to the cell periphery and prevented the formation of actin cortex and caused the appearance of F-actin stress fibers in polyamine depleted cells
Birukova et al., Am J Physiol Lung Cell Mol Physiol 2007
:
Paxillin-beta-catenin interactions are involved in
Rac/Cdc42 mediated endothelial barrier-protective response to oxidized phospholipids
Wu et al., Cell 2008
:
Rac1 activation
controls nuclear localization of
beta-catenin during canonical Wnt signaling ... Here we demonstrate that nuclear accumulation of
beta-catenin in response to Wnt
requires Rac1 activation
Upadhyay et al., Oncogene 2008
:
Molecular association between beta-catenin degradation complex and
Rac guanine exchange factor DOCK4 is
essential for
Wnt/beta-catenin signaling