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AKT1 — YWHAB

Pathways - manually collected, often from reviews:

• NCI Pathway Database a6b1 and a6b4 Integrin signaling: AKT1 (AKT1) → 14-3-3 family (YWHAH/YWHAZ/YWHAQ/SFN/YWHAE/YWHAG/YWHAB) (modification, activates)
  Santoro et al., Dev Cell 2003
  Evidence: assay, physical interaction
• NCI Pathway Database a6b1 and a6b4 Integrin signaling: AKT1 (AKT1) → Ron/MSP/14-3-3 family complex (MST1R-YWHAH_YWHAZ_YWHAQ_SFN_YWHAE_YWHAG_YWHAB-MST1) (modification, activates)
  Santoro et al., Dev Cell 2003
  Evidence: assay, physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• MIPS Negatome - no physical interaction between proteins Interaction: AKT1 — YWHAB (Absence of interaction, coimmunoprecipitation) Sato et al., J Biol Chem 2002*

Text-mined interactions from Literome

Guan et al., J Biol Chem 2000 : Furthermore, expression of Akt inhibits epidermal growth factor induced B-Raf activity and inhibition of Akt with LY294002 up-regulates B-Raf activity, suggesting that Akt negatively regulates B-Raf in vivo
Zhang et al., J Biol Chem 2001 : These results indicate that B-Raf kinase activity is negatively regulated by Akt and SGK, suggesting that the cross-talk between the B-Raf and other signaling pathways can be mediated by both Akt and SGK
Hong et al., Exp Cell Res 2013 (MAP Kinase Signaling System...) : Using androgen deprived LNCaP cells, in which ERK1/2 activation occurs in strong correlation with AKT activation, we found that AKT mediated B-Raf regulation is necessary for ERK1/2 activation