Marchionne et al., Am J Physiol Regul Integr Comp Physiol 2012
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Importantly, chronic renin inhibition is associated with upregulation of insulin action on skeletal muscle glucose transport, and it may involve improved Akt signaling
Cheng et al., Br J Pharmacol 2012
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Renin activates PI3K-Akt-eNOS signalling through the angiotensin AT1 and Mas receptors to modulate central blood pressure control in the nucleus tractus solitarii ... Immunoblotting and immunohistochemical studies further showed that inhibition of PI3K significantly blocked renin induced eNOS-Ser 117 and Akt-Ser473 phosphorylation in situ