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ANG — MMP2

Text-mined interactions from Literome

Kim et al., Circ Res 2000 : Ang1 induced the secretion of plasmin and matrix metalloproteinase-2 (MMP-2) , which is inhibited by PI 3'-kinase inhibitors
Chae et al., Arterioscler Thromb Vasc Biol 2000 (Disease Models, Animal) : Ang1 or VEGF induced migration and sprouting activity, increased plasmin and matrix metalloproteinase-2 secretion, and decreased tissue inhibitors of metalloproteinase type 2 secretion
Hu et al., Proc Natl Acad Sci U S A 2003 (Brain Neoplasms...) : A link between these two features was apparent, because stable expression of Ang2 by U87MG cells or treatment of several glioma cell lines with recombinant Ang2 in vitro caused activation of MMP-2 and acquisition of increased invasiveness
Arenas et al., Am J Physiol Cell Physiol 2004 : Moreover, ANG II induced MMP-2 release and reduced the secretion of tissue inhibitor of MMP (TIMP)-2 from endothelial cells
Samuel et al., Endocrinology 2004 (Cardiomyopathies...) : Relaxin also increased matrix metalloproteinase-2 expression in the presence of TGF-beta ( P < 0.01 ) and Ang II ( P < 0.05 )
Tsuruda et al., Biochem Biophys Res Commun 2004 : In cultured adventitial fibroblasts isolated from aorta of adult Wistar rats, 10 ( -6 ) mol/L angiotensin II (Ang II) significantly ( p < 0.05 ) down-regulated MMP-2 activity as determined by in vitro gelatin zymography
Hu et al., Cancer Res 2006 (Brain Neoplasms...) : In this study, we identify a novel mechanism by which Ang2 stimulates MMP-2 expression leading to glioma cell invasion ... Furthermore, expression of a negative regulator of FAK, FAK related nonkinase, by U87MG/Ang2 expressing glioma xenografts suppressed Ang2 induced MMP-2 expression and glioma cell infiltration in the murine brain
Flamant et al., Hypertension 2007 (Hypertension) : Ang II treatment induced MMP-2 and increased carotid media thickness equally in both phenotypes
Huang et al., Dig Dis Sci 2009 (Stomach Neoplasms) : It has been reported that angiotensin II (Ang II) can induce MMP2 expression in gastric cancer cells
Jing et al., Int J Mol Med 2009 : In untransfected VSMCs and stable transfectants with no AT2R induction, Ang II significantly increased the expression of matrix metalloproteinase 2 (MMP-2) , which is linked to neointimal growth
Martinez-Lemus et al., Am J Physiol Heart Circ Physiol 2011 (Disease Models, Animal...) : NE + ANG II also increased the arteriolar expression and activity of MMP-2 and the production of ROS as determined, respectively, by real-time RT-PCR, gel and in situ zymography, and the use of ROS-sensitive dyes with multiphoton microscopy ... Inhibition of MMP activation ( with GM-6001 ) or ROS production ( with apocynin or tempol ) prevented the NE + ANG II-induced inward remodeling
Pons et al., Am J Pathol 2011 (Hypertension...) : It has previously been reported that angiotensin II (Ang II) , one of the most important hormones associated with HTN, increases MMP-2 activity and its key regulator, MMP-14, in RPE, inducing breakdown of the RPE basement membrane, which may lead to progression of sub-RPE deposits
Gao et al., Ann Rheum Dis 2013 (Arthritis, Psoriatic...) : Finally, DAPT significantly decreased VEGF/Ang2 induced IL-6, IL-8, MMP2 and 9 expressions in RA synovial explants