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AKT3 — APOB

Text-mined interactions from Literome

Bussolati et al., J Am Soc Nephrol 2005 : In this study, oxidized LDL ( oxLDL ) but not native LDL induced apoptosis in human cultured podocytes and reduced Akt activity and P-Akt/Akt ratio
Namgaladze et al., Arterioscler Thromb Vasc Biol 2006 (Atherosclerosis) : PLA-LDL induced robust phosphorylation and activation of Akt in THP1 cells ... We noticed that lipid products derived from LDL phospholipolysis are mediators of PLA-LDL induced Akt activation
Preiss et al., Cardiovasc Res 2007 : We questioned whether members of the protein kinase C ( PKC ) family are involved in PLA-LDL induced Akt phosphorylation and survival of THP-1 monocytic cells ... Inhibitors of phospholipase C (PLC) or classical PKCs as well as PKC depletion following phorbol ester treatments, blocked Akt phosphorylation in response to PLA-LDL ... We show that PKCalpha and PKCbeta are critical for PLA-LDL induced Akt phosphorylation and survival in THP-1 monocytic cells
Favaro et al., Am J Pathol 2008 (Hyperglycemia) : Pravastatin ( 1 mumol/L ) decreased apoptosis induced by high glucose or oxidized LDL and increased Akt phosphorylation
Han et al., J Clin Invest 2009 (Atherosclerosis) : Adenovirus mediated hepatic expression of either constitutively active AKT or dominant negative glycogen synthase kinase ( GSK ) markedly increased VLDL and LDL levels such that they were similar in both Ldlr-/- and L1B6Ldlr-/- mice
Vicinanza et al., Thyroid 2013 : The aim of this study was to investigate the effects of both native LDL ( nLDL ) and oxLDL on T ( 3 ) -mediated AKT phosphorylation, nitric oxide ( NO ), and cyclic guanosine monophosphate ( cGMP ) production in human endothelial cells
Khaidakov et al., PloS one 2012 : Ox-LDL also triggered phosphorylation of I?Ba coupled with nuclear translocation of NF-?B and stimulated p44/42 MAPK, PI3K and Akt while intracellular PTEN ( PI3K/Akt pathway inhibitor and target of miR-21 ) declined ... Further, transfection of MCF10A cells with miR-21 inhibitor prevented ox-LDL mediated stimulation of PI3K and Akt
Cheng et al., International journal of biological sciences 2013 : AGE-LDL stimulation led to phosphorylation of JNK, p38, Akt and the p65 subunit of nuclear factor-?B ( NF-?B )