Takada et al., PPAR research 2012
:
Although BMP2 did not interfere with PPAR? mediated adipogenesis, BMP2 increased mRNA expression levels of PPAR? target genes ( such as Fabp4 and Nr1h3 ) when cells were first treated with troglitazone (TRO)
Hammarstedt et al., Proc Natl Acad Sci U S A 2013
:
WISP2 regulates preadipocyte commitment and PPAR? activation by BMP4 ... The importance of intracellular Wisp2 protein for BMP4 induced adipogenic commitment and PPAR? activation was verified by expressing a mutant Wisp2 protein lacking the endoplasmic reticulum signal and secretion sequence