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BMPR2 — SMAD6

Pathways - manually collected, often from reviews:

• NCI Pathway Database BMP receptor signaling: BMP2-4/BMPR2/BMPR1A-1B/RGM/XIAP complex (BMP4_BMP2-BMPR2-BMPR1A_BMPR1B-RGMB_RGMA_HFE2-XIAP) → TAK1/SMAD6 complex (MAP3K7-SMAD6) (modification, activates)
  Kimura et al., J Biol Chem 2000, Yamaguchi et al., EMBO J 1999
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database BMP receptor signaling: BMP7/BMPR2/BMPR1A-1B/SMAD6/SMURF1 complex (BMP7-BMPR2-BMPR1A_BMPR1B-SMAD6-SMURF1) → SMAD6/SMURF1 complex (SMAD6-SMURF1) (modification, collaborate)
  Murakami et al., Mol Biol Cell 2003, Hoodless et al., Cell 1996, Kretzschmar et al., Genes Dev 1997, Imamura et al., Nature 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database BMP receptor signaling: BMP7/BMPR2/BMPR1A-1B/SMAD6/SMURF1 complex (BMP7-BMPR2-BMPR1A_BMPR1B-SMAD6-SMURF1) → SMAD1 (SMAD1) (modification, collaborate) Murakami et al., Mol Biol Cell 2003, Hoodless et al., Cell 1996, Kretzschmar et al., Genes Dev 1997, Imamura et al., Nature 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database BMP receptor signaling: BMP7/BMPR2/BMPR1A-1B/SMAD6/SMURF1 complex (BMP7-BMPR2-BMPR1A_BMPR1B-SMAD6-SMURF1) → BMP7/BMPR2/BMPR1A-1B complex (BMP7-BMPR2-BMPR1A_BMPR1B) (modification, collaborate)
  Murakami et al., Mol Biol Cell 2003, Hoodless et al., Cell 1996, Kretzschmar et al., Genes Dev 1997, Imamura et al., Nature 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database BMP receptor signaling: SMAD6/SMURF1 complex (SMAD6-SMURF1) → BMP7/BMPR2/BMPR1A-1B complex (BMP7-BMPR2-BMPR1A_BMPR1B) (modification, collaborate)
  Murakami et al., Mol Biol Cell 2003, Hoodless et al., Cell 1996, Kretzschmar et al., Genes Dev 1997, Imamura et al., Nature 1997
  Evidence: mutant phenotype, assay, physical interaction
• Reactome Reaction: BMPR2 → SMAD6 (reaction) Ebisawa et al., J Biol Chem 2001, Suzuki et al., J Biol Chem 2002, Tajima et al., J Biol Chem 2003, Murakami et al., Mol Biol Cell 2003
• Reactome Reaction: BMPR2 → SMAD6 (indirect_complex) Ebisawa et al., J Biol Chem 2001, Suzuki et al., J Biol Chem 2002, Tajima et al., J Biol Chem 2003, Murakami et al., Mol Biol Cell 2003

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: BMPR2 — SMAD6 (physical association, affinity chromatography technology) Kamiya et al., J Biol Chem 2010

Text-mined interactions from Literome

Graham et al., Prostate 2009 (Neoplasm Metastasis...) : Notably, the activation of BMPRII by BMP-2 is required for modulation of Smad activation by NF-kappaB in PC cells
Yang et al., Ann N Y Acad Sci 2010 (Bone Diseases, Developmental) : This study provides an in vivo tool to study the role of BMPRII in BMP/Smad signaling and the regulation of this pathway by PTH and Wnts
Kudo et al., Tohoku J Exp Med 2010 : Tetracycline induced BMPRII-Flag expression significantly enhanced the induction of Id1, Id3, and Smad6 mRNA expression in FT293-BMPRII cells treated with BMP2