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CCL2 — CD40LG

Text-mined interactions from Literome

Kuroiwa et al., J Immunol 1999 (Glomerulonephritis) : Human peripheral blood monocytes, primed with IFN-gamma and GM-CSF, were activated with CD40 ligand (CD40L) or TNF-alpha and cocultured with MC. CD40L activated monocytes induced higher levels of IL-6, monocyte chemoattractant protein-1 ( MCP-1 ) and ICAM-1 synthesis by MC. Separation of CD40L activated monocytes from MC by a porous membrane decreased the mesangial synthesis of IL-6 by 80 % and ICAM-1 by 45 %, but had no effect on MCP-1
Sugiura et al., J Immunol 2000 (Dermatomyositis...) : Increased CD40 expression on muscle cells of polymyositis and dermatomyositis : role of CD40-CD40 ligand interaction in IL-6, IL-8, IL-15, and monocyte chemoattractant protein-1 production ... Recombinant human CD40L markedly increased the production of IL-6, IL-8, IL-15, and monocyte chemoattractant protein-1 of SkMC 2859
Verma et al., Circulation 2003 : The effects of resistin on expression of vascular cell adhesion molecule ( VCAM-1 ) and monocyte chemoattractant chemokine ( MCP-1 ) were studied in addition to CD40 receptor, CD40 ligand induced MCP-1 expression, and tumor necrosis factor receptor associated factor-3 ( TRAF3 ), an inhibitor of CD40 signaling ... Resistin did not alter CD40 receptor expression ; however, increased CD40 ligand induced MCP-1 production
Khan et al., Am J Physiol Gastrointest Liver Physiol 2005 (Disease Models, Animal...) : These results demonstrate that CD40-CD40 ligand interaction plays an important role in MCP-1 production, Th2 response, intestinal muscle hypercontractility, and worm expulsion in nematode infection
Pontrelli et al., J Am Soc Nephrol 2006 : The aim of this study was to investigate the effect of CD40/CD40L interaction on PTEC expression of plasminogen activator inhibitor-1 ( PAI-1 ), a powerful profibrotic mediator, and monocyte chemoattractant protein-1 ( MCP-1 ), a proinflammatory cytokine, and to investigate the signaling pathways that lead to these effects ... Soluble CD40L induced a time dependent increase in both PAI-1 and MCP-1 gene expression and protein production in PTEC ... Lyn inhibition did not have any effect on CD40L induced NF-kappaB activation and MCP-1 expression but abolished PAI-1 induction
Zirlik et al., Arterioscler Thromb Vasc Biol 2007 (Atherosclerosis...) : Whereas TRAF-1 deficiency enhanced CD40L induced IL-6 and MCP-1 expression, TRAF-2 and TRAF-5 deficiency inhibited CD40L-inducible IL-6 but not MCP-1 expression ... TRAF-3 silencing in ECs showed increased CD40L induced IL-6, MCP-1 , and IL-8 expression, whereas TRAF-6 silencing increased selectively CD40L induced MCP-1 expression
Stumpf et al., Heart 2008 (Cardiomyopathy, Dilated...) : In the cell coculture model activated platelets were able to significantly induce MCP-1 release from HUVEC in a CD154 dependent manner
Lee et al., Nephrol Dial Transplant 2010 (Disease Models, Animal...) : In vitro, CD154 blockade significantly attenuated upregulation of CCL2 gene expression by RTEC stimulated by activated macrophage conditioned medium
Missiou et al., Thromb Haemost 2010 (Cardiovascular Diseases...) : Stimulation with recombinant CD40L or membranes over expressing CD40L induced a time- and dose dependent expression of IL-6, MCP-1 , IL-8, and PAI-1