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CSF2 — HRAS
Pathways - manually collected, often from reviews:
-
NCI Pathway Database GMCSF-mediated signaling events:
GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/SOS1 complex (CSF2RB-JAK2-SHC1-CSF2-CSF2RA-GRB2-SOS1)
→
RAS family/GDP complex (HRAS_KRAS_HRAS_KRAS_NRAS)
(modification, activates)
Piu et al., Oncogene 2002, Guthridge et al., Blood 2004, Lanfrancone et al., Oncogene 1995, Sato et al., EMBO J 1993
Evidence: mutant phenotype, assay
-
NCI Pathway Database GMCSF-mediated signaling events:
GMCSF/GMR alpha/CSF2RB/JAK2 (dodecamer)/SHC/GRB2/SOS1 complex (CSF2RB-JAK2-SHC1-CSF2-CSF2RA-GRB2-SOS1)
→
RAS family/GTP complex (HRAS_KRAS_HRAS_KRAS_NRAS)
(modification, activates)
Piu et al., Oncogene 2002, Guthridge et al., Blood 2004, Lanfrancone et al., Oncogene 1995, Sato et al., EMBO J 1993
Evidence: mutant phenotype, assay
-
Reactome Reaction:
CSF2
→
HRAS
(reaction)
Chardin et al., Science 1993
Text-mined interactions from Literome
Duronio et al., Proc Natl Acad Sci U S A 1992
:
We demonstrate here that ligand induced activation of the interleukin (IL)-2, IL-3, IL-5, and granulocyte-macrophage
colony stimulating factor receptors
resulted in activation of
p21ras in various hemopoietic cell lines
Baumann et al., Leuk Res 2005
:
Both G-CSF and
GM-CSF caused activation of
p21 ras in neutrophils, demonstrating that early events in the ras-MAPK pathway remain functional after stimulation by either cytokine
Csar et al., Biochem J 1997
(Leukemia, Myeloid) :
cAMP suppresses
p21ras and Raf-1 responses but not the Erk-1
response to
granulocyte-colony stimulating factor : possible Raf-1 independent activation of Erk-1
Wilson et al., Biochem Biophys Res Commun 1998
:
In contrast,
CSF-1 stimulated
p21Ras activity was blocked by 8BrcAMP thus correlating with the inhibition of proliferation