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GAST — IL1B

Text-mined interactions from Literome

Chakravorty et al., Int J Biochem Cell Biol 2009 : Gastrin promoter assay showed that IL1B inhibits gastrin expression at the transcriptional level and part of this inhibitory process is mediated via activation of NFkappaB and involvement of HDACs
Datta De et al., PloS one 2011 : IL1B induced Smad 7 negatively regulates gastrin expression ... However, we hypothesized that regulation of gastrin by IL1B would depend on the cell 's ability to integrate inputs from multiple signaling pathways to generate appropriate biological response
Weigert et al., Gastroenterology 1996 : Interleukin (IL) 1 beta ( 50 % effective concentration [ EC50 ], 5.3 +/- 0.4 ng/mL ) and tumor necrosis factor (TNF) alpha ( EC50, 5.5 +/- 0.5 ng/mL ) stimulated gastrin release to 50 % of the maximal response to 10 ( -9 ) mol/L neuromedin C. Stimulation by the maximally effective concentration of IL-1 beta ( 10 ng/mL ) was inhibited by the human IL-1 receptor antagonist ( 100 ng/mL ; inhibitory constant, 23.0 ng/mL ), which prefers type I over type II IL-1 receptors ... IL-1 beta and TNF-alpha stimulate gastrin secretion via receptors potentially residing on rabbit antral G cells themselves