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HDAC2 — SP1

Pathways - manually collected, often from reviews:

• FastForward regulation: SP1 → HDAC2 (transcriptional regulation, unknown)
  Evidence: DNABINDING
• NCI Pathway Database Regulation of Telomerase: SP3/HDAC2 complex (SP3-HDAC2) → SP1 (SP1) (transcription, inhibits) Kyo et al., Nucleic Acids Res 2000*, Won et al., J Biol Chem 2002*
• NCI Pathway Database Regulation of Telomerase: SP3/HDAC2 complex (SP3-HDAC2) → SP1/HDAC2 complex (SP1-HDAC2) (transcription, inhibits)
  Kyo et al., Nucleic Acids Res 2000*, Won et al., J Biol Chem 2002*
• NCI Pathway Database Regulation of Telomerase: MYC (MYC) → SP1/HDAC2 complex (SP1-HDAC2) (transcription, activates)
  Kyo et al., Nucleic Acids Res 2000*, Won et al., J Biol Chem 2002*
• NCI Pathway Database Regulation of Telomerase: SP1 (SP1) → SP1/HDAC2 complex (SP1-HDAC2) (transcription, activates)
  Kyo et al., Nucleic Acids Res 2000*, Won et al., J Biol Chem 2002*

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: HDAC2 — SP1 (physical association, affinity chromatography technology) Won et al., J Biol Chem 2002*
• IRef Biogrid Interaction: HDAC2 — SP1 (physical association, affinity chromatography technology) Sun et al., J Biol Chem 2002*
• IRef Biogrid Interaction: HDAC2 — SP1 (physical association, affinity chromatography technology) Glasspool et al., Neoplasia (New York, N.Y.) 2005*
• IRef Biogrid Interaction: HDAC2 — SP1 (physical association, affinity chromatography technology) Sekhavat et al., Biochem Cell Biol 2007*
• IRef Biogrid Interaction: HDAC2 — SP1 (physical association, affinity chromatography technology) Tsai et al., J Virol 2011*
• IRef Biogrid Interaction: HDAC2 — SP1 (physical association, affinity chromatography technology) Marshall et al., Oncogene 2010*
• IRef Biogrid Interaction: HDAC2 — SP1 (physical association, affinity chromatography technology) Itoh et al., J Immunol 2007*
• IRef Biogrid Interaction: HDAC2 — SP1 (physical association, affinity chromatography technology) Duan et al., Mol Cell Biol 2005*
• IRef Biogrid Interaction: HDAC2 — SP1 (physical association, affinity chromatography technology) Schnur et al., Biochim Biophys Acta 2007*
• IRef Biogrid Interaction: HDAC2 — SP1 (physical association, affinity chromatography technology) Zhang et al., J Biol Chem 2002*
• MIPS CORUM HCF-1 complex: HCF-1 complex complex (ASH2L-HCFC1-HDAC1-HDAC2-HSPA4-HSPA5-HSPA8-OGT-RBBP4-RBBP7-SAP30-SETD1A-SIN3A-SIN3B-SP1-SUDS3-WDR5-HSP90AA1-HSP90AB1) Wysocka et al., Genes Dev 2003
• IRef Corum Interaction: Complex of 20 proteins (association, anti tag coimmunoprecipitation) Wysocka et al., Genes Dev 2003
• IRef Hprd Interaction: HDAC2 — SP1 (in vivo) Won et al., J Biol Chem 2002*
• IRef Intact Interaction: Complex of SP1-HDAC2-SP1-MYCN-HDAC2-MYCN (physical association, anti bait coimmunoprecipitation) Marshall et al., Oncogene 2010*
• IRef Intact Interaction: Complex of 14 proteins (association, anti tag coimmunoprecipitation) Wysocka et al., Genes Dev 2003
• IRef Ophid Interaction: HDAC2 — SP1 (aggregation, confirmational text mining) Won et al., J Biol Chem 2002*
• IRef Ophid Interaction: HDAC2 — SP1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Sowa et al., Cancer Res 1999 : Sp3, but not Sp1 , mediates the transcriptional activation of the p21/WAF1/Cip1 gene promoter by histone deacetylase inhibitor
Ryu et al., Proc Natl Acad Sci U S A 2003 : Histone deacetylase (HDAC) inhibitors augment Sp1 acetylation, Sp1 DNA binding, and Sp1 dependent gene expression and confer resistance to oxidative stress induced death in vitro and in vivo
Yang et al., Epigenetics 2012 : CD1d induction in solid tumor cells by histone deacetylase inhibitors through inhibition of HDAC1/2 and activation of Sp1 ... These results indicate that TSA and SAHA could up-regulate CD1d expression in tumor cells through inhibition of HDAC1/2 and activation of Sp1