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IKBKG — NOX3
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Wu et al., Free Radic Biol Med 2009
(Inflammation...) :
Collectively, the results of this study and those of previous reports indicate that the conversion of cardiomyocytes to a proinflammatory phenotype in sepsis involves two distinct pathways :
NADPH oxidase mediated phosphorylation of
IKK and p38 MAP kinase
mediated phosphorylation of p65
Menden et al., Am J Physiol Lung Cell Mol Physiol 2013
:
LPS mediated endothelial activation in pulmonary endothelial cells : role of
Nox2 dependent
IKK-ß phosphorylation ... We examined whether
Nox2 dependent, LPS mediated
IKK-ß phosphorylation was
regulated by protein phosphatase 2A (PP2A) or TGF-ß associated kinase-1 (TAK1) in HPMEC
Valente et al., Free Radic Biol Med 2013
:
Advanced oxidation protein products induce cardiomyocyte death via
Nox2/Rac1/superoxide dependent
TRAF3IP2/JNK signaling ... AOPP-MSA stimulated
Nox2/Rac1 dependent superoxide generation,
TRAF3IP2 expression, and TRAF3IP2 dependent JNK activation ... These results demonstrate for the first time that AOPPs induce cardiomyocyte death via
Nox2/Rac1/superoxide dependent
TRAF3IP2/JNK activation in vitro and suggest that AOPPs may contribute to myocardial injury in vivo