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INS — INSIG2

Text-mined interactions from Literome

Yabe et al., Proc Natl Acad Sci U S A 2003 : Insig-2a is the predominant transcript in livers of fed animals, and it is selectively down-regulated by insulin
Yellaturu et al., J Biol Chem 2009 : Insulin induced depletion of Insig-2a promotes association of the SCAP.SREBP-1c complex with COPII vesicles and subsequent migration to the Golgi where site-1 and site-2 proteases process the nascent SREBP-1c
Fernández-Alvarez et al., J Biol Chem 2010 : Moreover, our findings suggest that insulin activated the human INSIG2 promoter in a process mediated by phosphorylated SAP1a
Chen et al., J Biomed Sci 2011 : In addition, Insig-1 up-regulated the expression of IRS-2, PDX-1, GLUT-2 and Insulin , down-regulated the expression of UCP-2 and improved glucose stimulated insulin secretion ( GSIS )
Boden et al., Obesity (Silver Spring) 2013 : Comparison of in vivo effects of insulin on SREBP-1c activation and INSIG-1/2 in rat liver and human and rat adipose tissue