Gene interactions and pathways from curated databases and text-mining

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CREBBP — PGR

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: CREBBP → Complex of PGR-SRC (increases, PGR/SRC Activity)
    Evidence: Upon ligand treatment, progesterone receptor (PR) interacted preferentially with SRC-1 which recruited CBP and significantly enhanced acetylation at K5 of histone H4.