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JUN — PKD1

Text-mined interactions from Literome

Hurd et al., Biochem Biophys Res Commun 2001 : Induced expression of constitutively active, but not kinase dead PKD, suppressed EGF stimulated c-Jun phosphorylation at Ser 63, demonstrating that activated PKD is sufficient to suppress c-Jun phosphorylation
Parnell et al., J Biol Chem 2002 : Polycystin-1 activation of c-Jun N-terminal kinase and AP-1 is mediated by heterotrimeric G proteins ... Polycystin-1 mediated AP-1 activity could be significantly augmented by cotransfected Galpha ( i ), Galpha ( q ), and Galpha(12/13) subunits, suggesting that polycystin-1 can couple with and activate several heterotrimeric G protein families
Yamashita et al., Int Immunopharmacol 2010 : We investigated the roles of PKD on FcepsilonRI induced activator protein-1 (AP-1) activation and proinflammatory cytokine productions in mast cells ... The overexpression of PKD enhanced the induction of AP-1 luciferase activity by FcepsilonRI stimulation, while it had no effect on luciferase activities dependent upon NF-kappaB and NF-AT activated by FcepsilonRI stimulation ... Moreover the overexpression of PKD strongly enhanced the phosphorylation of both c-Jun and c-Fos following FcepsilonRI stimulation
Arnould et al., J Biol Chem 1998 (Polycystic Kidney, Autosomal Dominant) : The polycystic kidney disease 1 gene product mediates protein kinase C alpha dependent and c-Jun N-terminal kinase dependent activation of the transcription factor AP-1 ... In vitro kinase assays revealed that PKD1 triggers the activation of c-Jun N-terminal kinase (JNK) , but not of mitogen activated protein kinases p38 or p44 ... Dominant negative Rac-1 and Cdc42 mutations abrogated PKD1 mediated JNK and AP-1 activation, suggesting a critical role for small GTP binding proteins in PKD1 mediated signaling ... Several protein kinase C ( PKC ) inhibitors decreased PKD1 mediated AP-1 activation