Gene interactions and pathways from curated databases and text-mining

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IL1B — PRL

Text-mined interactions from Literome

Gerlo et al., J Neuroimmunol 2005 : PRL mRNA expression was inhibited to a lesser extent by IL-1beta , which decreased PRL mRNA levels to 58 % of control values
Lee et al., Cancer Res 2005 (MAP Kinase Signaling System) : To delineate the signaling mechanism from 16-kDa PRL, we examined the effect of 16-kDa PRL on interleukin IL-1beta-inducible iNOS expression, which is regulated by two parallel pathways, one involving IFN regulatory factor 1 (IRF-1) and the other nuclear factor-kappaB (NF-kappaB)
Skurlova et al., Endocr Regul 2006 : Exogenous IL-1beta induces its own expression, but not that of IL-6 in the hypothalamus and activates HPA axis and prolactin release
Yamaguchi et al., Endocrinol Jpn 1991 : The effects of human recombinant interleukin-1 beta and -6 and tumor necrosis factor-alpha (TNF-alpha) on the releases of PRL and dopamine were examined using monolayer cultures of rat pituitary cells and hypothalamic cells ... The release of PRL from rat pituitary cells in 30 min was increased about 2-fold ( p less than 0.05 ) by 10 ( 5 ) U/l interleukin-1 beta , 10 ( 5 ) U/l interleukin-6 or 100 micrograms/l TNF-alpha
Tripathi et al., Int Immunol 2008 : AG490, inhibitor of JAK2, down-regulated transcription factors c-jun and STAT1 and inhibited the PRL induced IFN-gamma, TNF-alpha, IL-1 beta and IL-12p40 production in macrophages
Sodhi et al., Growth Factors 2008 (Calcium Signaling...) : The involvement of Ca++ signaling and p42/44 MAP kinase in regulation of PRL induced IL-1beta and TNF-alpha production by macrophages has also been investigated
Brunetti et al., Life Sci 1995 : A possible role for nitric oxide but not for prostaglandin E2 in basal and interleukin-1-beta induced PRL release in vitro ... Now, we show experimental evidence of an involvement of NO in basal and interleukin-1 beta induced prolactin (PRL) release ... L-NG-nitro-arginine, an inhibitor of nitric oxide synthetase, and hemoglobin, a NO scavenger, impaired basal and interleukin-1-beta induced PRL release, while molsidomine, a NO donor, was able to release PRL and to amplify interleukin-1-beta induced PRL release, confirming a modulatory role for nitric oxide in pituitary hormone secretion ... On the other hand, no evidence regarding a possible role of prostaglandin E2 ( PGE2 ) in IL-1beta induced PRL release came out from our experiments
Turnbull et al., Neuroimmunomodulation 1995 : The absence of a comparable change in the progesterone release rate of males infused with IL-1 beta, and the presence of marked surges of prolactin (PRL) in the females, suggests that IL-1 beta altered ovarian function, and that the persistence of large corpora lutea induced PRL release
Tseng et al., Mol Cell Endocrinol 1997 : Here, we investigated the effects of GH and PRL on the expression of interleukin (IL)-1alpha, IL-1beta and IL-6 in thymic stromal cells (TSC)