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PTGS2 — SP1

Text-mined interactions from Literome

Xu et al., J Biol Chem 2000 : Sp1 increases expression of cyclooxygenase-2 in hypoxic vascular endothelium ... We hypothesized that Sp1 is involved in the induction of cox-2 in hypoxic HUVEC ... Overexpression of Sp1 through transfection of HUVEC enhanced cox-2 promoter activity as measured by reporter gene expression and by the production of COX-2
Han et al., Int J Cancer 2005 (Carcinoma, Non-Small-Cell Lung...) : Gel mobility shift assays showed that the COX-2 inhibitors increased Sp1 DNA binding, but decreased that of AP-1
Abdelrahim et al., Mol Pharmacol 2005 (Colonic Neoplasms) : COX-2 inhibitors do not affect Sp1 or Sp4 mRNA levels in SW-480 cells ; however, decreased expression of both proteins was accompanied by increased protein ubiquitination and inhibited by the proteasome inhibitor gliotoxin