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MMP9 — STAT3

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: MMP9 → STAT3 (increases, MMP9 Activity)
  Evidence: and it induces the expression of genes that are involved in invasion and metastasis, such as the matrix metalloproteinase 9 (MMP9) [29].

Text-mined interactions from Literome

Nagata et al., Arterioscler Thromb Vasc Biol 2003 : A MEK1 inhibitor, PD98059, not only blocked ERK1/2 phosphorylation but also abolished the OSM induced MMP-9 upregulation, whereas the MMP-9 induction was not affected by overexpressing dominant negative STAT3
Dechow et al., Proc Natl Acad Sci U S A 2004 (Breast Neoplasms...) : Here, we demonstrate that a constitutively activated Stat3 transforms immortalized human mammary epithelial cells and that this oncogenic event requires the activity of matrix metalloproteinase-9 (MMP-9)
Song et al., Mol Immunol 2008 (Neoplasm Invasiveness) : Fra-1 and Stat3 synergistically regulate activation of human MMP-9 gene ... Our study demonstrated that the activation of MMP-9 promoter is dependent upon interactions of Fra-1/c-Jun with Stat3
Leong et al., Breast Cancer Res Treat 2009 (Breast Neoplasms...) : Transient expression of constitutively active STAT3 significantly reduced the inhibitory effect of Poly E on cell migration and VEGF and MMP9 expression
Kim et al., Exp Mol Med 2008 (Breast Neoplasms...) : We found that LYR71 suppressed STAT3 activation and inhibited the expression and activity of MMP-9 in RANTES stimulated breast cancer cells ... Taken together, the results of this study suggest that LYR71 can be therapeutically useful due to the inhibition effect of STAT3 mediated MMP-9 expression in breast cancer cells
Schröer et al., Cancer Res 2011 (Uterine Cervical Neoplasms) : Our data provide evidence that STAT3 does not directly induce MMP-9 but first leads to a strong production of the monocyte chemoattractant protein-1 ( CCL2 ) in the nanogram range
Yi et al., Ann Surg Oncol 2013 (Carcinoma, Hepatocellular...) : IRF-2/IRF-1 ratio was associated with tumor invasion, probably through modulation of MMP9 expression mediated by STAT3
Guo et al., Mol Cancer Ther 2013 (Neoplasm Invasiveness...) : NE-mediated activation of STAT3 was inhibited by blocking ß-adrenergic receptors ( AR ) and by blocking protein kinase A, but not through blocking a-AR. Blocking STAT3 could inhibit NE-induced NGF, MMP2, and MMP9 expression and attenuate the migratory, invasive ability and PNI of pancreatic cancer cells