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CA2 — TRPM8

Text-mined interactions from Literome

Kraft et al., Br J Pharmacol 2006 (Calcium Signaling) : TRPC6 mediated currents ( IC50 = 2.3 microM ) and TRPM8 induced Ca2+ signals ( IC50 = 3.9 microM ) were blocked in a concentration dependent manner
Mahieu et al., J Biol Chem 2007 (Calcium Signaling) : Here we show that menthol induces Ca2+ release from intracellular stores in four widely used cell lines ( HEK293, lymph node carcinoma of the prostate ( LNCaP ), Chinese hamster ovary ( CHO ), and COS ), and provide several lines of evidence indicating that this release pathway is TRPM8 independent : 1 ) menthol induced Ca2+ release was potentiated at higher temperatures, which contrasts to the cold activation of TRPM8 ; 2 ) overexpression of TRPM8 did not enhance the menthol induced Ca2+ ) release ; 3 ) menthol induced Ca2+ release was mimicked by geraniol and linalool, which are structurally related to menthol, but not by the more potent TRPM8 agonists icilin or eucalyptol ; and 4 ) TRPM8 expression in HEK293 cells was undetectable at the protein and mRNA levels
De Petrocellis et al., J Pharmacol Exp Ther 2008 : In this study, we investigated the effects of six phytocannabinoids [ i.e., CBD, THC, CBD acid, THC acid, cannabichromene (CBC), and cannabigerol (CBG) ] on TRPA1- and TRPM8 mediated increase in intracellular Ca2+ in either HEK-293 cells overexpressing the two channels or rat dorsal root ganglia ( DRG ) sensory neurons