Rigor et al., J Cereb Blood Flow Metab 2010
:
In this study, we used isolated rat brain capillaries to show that the TNF-alpha induced reduction of P-glycoprotein activity was prevented by a PKCbeta ( I/II ) inhibitor, LY333531, and mimicked by a PKCbeta ( I/II ) activator, 12-deoxyphorbol-13-phenylacetate-20-acetate ( dPPA ) ... Thus, PKCbeta ( I ) activation selectively reduced P-glycoprotein activity both in vitro and in vivo
Hawkins et al., J Cereb Blood Flow Metab 2010
:
Thus, VEGF and PKCbeta1 reduce P-glycoprotein activity by distinct mechanisms