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MAP2K1 — TP53

Text-mined interactions from Literome

Ryan et al., Nature 2000 : Activation of NF-kappaB by p53 was distinct from that mediated by tumour-necrosis factor-alpha and involved MEK1 and the activation of pp90rsk ... Inhibition of MEK1 blocked activation of NF-kappaB by p53 and completely abrogated p53 induced cell death
She et al., Cancer Res 2001 : Furthermore, pretreatment of the cells with PD98059 or SB202190 or stable expression of a dominant negative mutant of ERK2 or p38 kinase impaired resveratrol induced p53 dependent transcriptional activity and apoptosis, whereas constitutively active MEK1 increased the transcriptional activity of p53
She et al., Oncogene 2002 : In contrast, dominant negative ERK2 or the MEK1 inhibitor, PD98059, had no effect on p53 phosphorylation at serine 20
Ferbeyre et al., Mol Cell Biol 2002 (MAP Kinase Signaling System) : In contrast, coexpression of oncogenic ras or activated mek1 with p53 enhanced both p53 levels and activity relative to that observed for p53 alone and produced an irreversible cell cycle arrest that displayed features of cellular senescence
Bao et al., J Cell Biol 2004 (MAP Kinase Signaling System...) : Surprisingly, MEK1 and ERK1/2 activities were restored in integrin alphav negative melanoma cells by suppression of p53 , whereas concomitant block of MEK1 induced apoptosis ... This suggests that integrin alphav controls melanoma cell survival in 3D-collagen through a pathway involving p53 regulation of MEK1 signaling
Hawkes et al., J Biol Chem 2012 (MAP Kinase Signaling System) : We report here that delayed cell cycle progression, Ser-33 phosphorylation, and p53 nuclear accumulation from SEPW1 depletion require mitogen activated protein kinase kinase 4 ( MKK4 )