Cheng et al., Drug Metab Dispos 2005
:
All chemicals increased the expression of their well characterized target drug metabolizing enzymes : AhR ligands increased Cyp1A1, CAR activators increased Cyp2B10, PXR ligands increased Cyp3A11, PPARalpha ligands increased Cyp4A14, and Nrf2 activators induced NAD(P)H:quinone oxidoreductase 1
Villard et al., Biochem Biophys Res Commun 2007
:
PPARalpha transcriptionally induces AhR expression in Caco-2, but represses AhR pro-inflammatory effects
Wang et al., Environ Health Perspect 2011
(Insulin Resistance) :
Aryl hydrocarbon receptor deficiency enhances insulin sensitivity and reduces PPAR-a pathway activity in mice ... AhR agonists and small interfering RNA ( siRNA ) were used to examine the effect of AhR on PPAR-a expression and glycolysis in the liver cell line Hepa-1c1c7 ( c7 ) and its c12 and c4 derivatives