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ARHGEF25 — RAC1

Pathways - manually collected, often from reviews:

• NCI Pathway Database Regulation of RAC1 activity: RAC1/GDP complex (RAC1) → GEFT (ARHGEF25) (modification, collaborate) Waterman-Storer et al., Nat Cell Biol 1999*, Guo et al., J Biol Chem 2003*
  Evidence: assay, physical interaction
• NCI Pathway Database Regulation of RAC1 activity: GEFT (ARHGEF25) → RAC1/GTP complex (RAC1) (modification, activates) Waterman-Storer et al., Nat Cell Biol 1999*, Guo et al., J Biol Chem 2003*
  Evidence: assay, physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: RAC1 — ARHGEF25 (direct interaction, pull down) Guo et al., J Biol Chem 2003*
• IRef Hprd Interaction: RAC1 — ARHGEF25 (in vitro) Guo et al., J Biol Chem 2003*

Text-mined interactions from Literome

Lutz et al., Naunyn Schmiedebergs Arch Pharmacol 2004 (Urinary Bladder Neoplasms) : When expressed in human embryonic kidney cells, both p63RhoGEF and GEFT caused activation of RhoA, but not Rac1 or Cdc42, and induced serum response factor mediated gene transcription, which was fully blunted by the Rho inactivating C3 transferase
Wuertz et al., FASEB J 2010 : p63RhoGEF is not an activator of the concomitant Rac1 activation and functions independently of caveolae