◀ Back to BAD
BAD — BCL2
Pathways - manually collected, often from reviews:
-
BioCarta regulation of bad phosphorylation:
BAD
→
BAD/BCL-2 complex (BAD-BCL2)
(modification, collaborate)
-
BioCarta regulation of bad phosphorylation:
BAD
→
BCL-2 (BCL2)
(modification, collaborate)
-
BioCarta regulation of bad phosphorylation:
BAD/BCL-2 complex (BAD-BCL2)
→
BCL-2 (BCL2)
(modification, collaborate)
-
BioCarta regulation of bad phosphorylation:
BAD
→
BAD/BCL-2 complex (BAD-BCL2)
(modification, collaborate)
-
BioCarta regulation of bad phosphorylation:
BAD
→
BCL-2 (BCL2)
(modification, collaborate)
-
BioCarta regulation of bad phosphorylation:
BAD/BCL-2 complex (BAD-BCL2)
→
PKA complex (PRKACB-PRKACG-PRKAR1A-PRKAR1B-PRKAR2A-PRKAR2B)
(modification, collaborate)
-
BioCarta regulation of bad phosphorylation:
BAD/BCL-2 complex (BAD-BCL2)
→
BCL-2 (BCL2)
(modification, collaborate)
-
BioCarta regulation of bad phosphorylation:
BAD/BCL-2 complex (BAD-BCL2)
→
AKT (AKT1)
(modification, collaborate)
-
KEGG Tuberculosis:
BAD
→
BCL2
(protein-protein, dissociation)
-
Reactome Reaction:
BAD
→
BCL2
(reaction)
-
Reactome Reaction:
BAD
→
BCL2
(direct_complex)
-
WikiPathways DNA Damage Response (only ATM dependent):
BAD
→
BCL2
(inhibition)
Strasser et al., Nat Rev Immunol 2005
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Bind_translation Interaction:
BAD
—
BCL2
(two hybrid)
Inohara et al., EMBO J 1997*
-
IRef Bind_translation Interaction:
BAD
—
BCL2
(coimmunoprecipitation)
Chen et al., Mol Cell 2005
-
IRef Bind_translation Interaction:
BAD
—
BCL2
(competition binding)
Chen et al., Mol Cell 2005
-
IRef Bind_translation Interaction:
BAD
—
BCL2
(coimmunoprecipitation)
Edlich et al., EMBO J 2005
-
IRef Bind_translation Interaction:
BAD
—
BCL2
(affinity chromatography technology)
Edlich et al., EMBO J 2005
-
IRef Bind_translation Interaction:
BAD
—
BCL2
(two hybrid)
Cartron et al., Mol Cell 2004*
-
IRef Biogrid Interaction:
BAD
—
BCL2
(physical association, affinity chromatography technology)
Yang et al., Cell 1995*
-
IRef Biogrid Interaction:
BAD
—
BCL2
(direct interaction, two hybrid)
Yang et al., Cell 1995*
-
IRef Biogrid Interaction:
BAD
—
BCL2
(physical association, affinity chromatography technology)
Edlich et al., EMBO J 2005
-
IRef Biogrid Interaction:
BAD
—
BCL2
(direct interaction, pull down)
Jin et al., J Biol Chem 2005*
-
IRef Biogrid Interaction:
BAD
—
BCL2
(physical association, affinity chromatography technology)
Chen et al., Mol Cell 2005
-
IRef Innatedb Interaction:
BAD
—
BCL2
(unknown, -)
Jin et al., J Biol Chem 2005*
-
IRef Intact Interaction:
BAD
—
BCL2
(direct interaction, inferred by curator)
Hermjakob et al., Nucleic Acids Res 2004
-
IRef Intact Interaction:
BAD
—
BCL2
(direct interaction, surface plasmon resonance)
Chen et al., Mol Cell 2005
-
IRef Intact Interaction:
BAD
—
BCL2
(physical association, anti bait coimmunoprecipitation)
Maiuri et al., EMBO J 2007*
-
IRef Intact Interaction:
BAD
—
BCL2
(physical association, two hybrid)
Ottilie et al., J Biol Chem 1997*
-
IRef Intact Interaction:
BAD
—
BCL2
(physical association, enzyme linked immunosorbent assay)
Ottilie et al., J Biol Chem 1997*
-
IRef Intact Interaction:
BAD
—
BCL2
(physical association, anti bait coimmunoprecipitation)
Huang et al., EMBO J 1998*
-
IRef Ophid Interaction:
BAD
—
BCL2
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Pastorino et al., J Biol Chem 1999
:
Phosphorylation of
BAD prevents its interaction with the antiapoptotic protein
Bcl-XL
Condorelli et al., Mol Cell Biol 2001
:
The generation of truncated
BAD was
blocked by
Bcl-2 in IL-3 deprived 32Dcl3 cells but not in Jurkat T cells exposed to anti-FAS antibody, TNF-alpha, or TRAIL
Singh et al., Molecular cancer 2009
(Neoplasm Invasiveness...) :
IL-8 depletion caused significant decreases in anti-apoptotic proteins, BCL-2,
BCL-xL due to decrease in both mRNA and post-translational stability, and increased levels of pro-apoptotic BAX and
BAD proteins
Malla et al., J Neurooncol 2012
(Glioma) :
In the present study, efficient downregulation of uPAR and cathepsin B increased the translocation of calcineurin A from the mitochondria to the cytosol, decreased pBAD ( S136 ) expression and its interaction with 14-3-3? and
increased the interaction of
BAD with
Bcl-xl