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CD34 — TGFB1

Text-mined interactions from Literome

Xiao et al., Exp Hematol 2001 : TGF-beta(1) reduced CD34 ( + ) CD38 ( + ) cell expansion and arrested cell division
Marone et al., Leukemia 2002 (Leukemia, Erythroblastic, Acute...) : Transforming growth factor-beta1 transcriptionally activates CD34 and prevents induced differentiation of TF-1 cells in the absence of any cell-cycle effects ... In the present work, we show that exogenous TGF-beta1 upregulates the human CD34 antigen in the CD34 ( + ) cell lines TF-1 and KG-1a, but not in the more differentiated CD34 ( - ) cell lines HL-60 and K-562 ... Our data demonstrate that TGF-beta1 transcriptionally activates CD34 and prevents differentiation of TF-1 cells by acting independently through the Smad, TAK1 and p38 pathways, and thus provide important clues for the understanding of hematopoietic development and a potential tool to modify response of hematopoietic cells to mitogens or differentiating agents
Pierelli et al., Br J Haematol 2002 : Transforming growth factor-beta1 causes transcriptional activation of CD34 and preserves haematopoietic stem/progenitor cell activity ... Here, we have shown that TGF-beta1 upregulates the human CD34 , an effect that was evident in primary stem/progenitor cells ( CD34+lin- ) both at the transcriptional and protein levels, and was not associated with any relevant effect on cell growth
Van Ranst et al., Exp Hematol 1996 : We investigated the effects of transforming growth factor-beta ( TGF-beta ) and macrophage inflammatory protein-1 alpha ( MIP-1 alpha ) on very primitive CD34++CD38- and on more mature CD34++CD38+ human hematopoietic progenitor cells by means of a two stage pre-colony forming cell ( pre-CFC ) assay