◀ Back to TNFSF10

FASLG — TNFSF10

Pathways - manually collected, often from reviews:

• NCI Pathway Database Caspase Cascade in Apoptosis: TRAIL/TRAILR2/FADD complex (TNFRSF10B-FADD-TNFSF10) → FASLG/FAS (trimer)/FADD/FADD complex (FAS-FASLG-FADD) (modification, activates)
  Bodmer et al., Nat Cell Biol 2000, Sprick et al., Immunity 2000, Schneider-Brachert et al., Immunity 2004, Schneider-Brachert et al., J Clin Invest 2006, Lavrik et al., J Biol Chem 2008, Boldin et al., Cell 1996, Walczak et al., EMBO J 1997, Scaffidi et al., EMBO J 1998
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Caspase Cascade in Apoptosis: TRAIL/TRAILR2/FADD complex (TNFRSF10B-FADD-TNFSF10) → FASLG/FAS (trimer)/FADD/FADD complex (FAS-FASLG-FADD) (modification, activates)
  Wang et al., Proc Natl Acad Sci U S A 2001, Garg et al., Indian J Pediatr 1977, Walczak et al., EMBO J 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Caspase Cascade in Apoptosis: TRAIL/TRAILR1/FADD complex (TNFRSF10A-FADD-TNFSF10) → FASLG/FAS (trimer)/FADD/FADD complex (FAS-FASLG-FADD) (modification, activates)
  Wang et al., Proc Natl Acad Sci U S A 2001, Garg et al., Indian J Pediatr 1977, Walczak et al., EMBO J 1997
  Evidence: mutant phenotype, assay, physical interaction

Text-mined interactions from Literome

Mehmut et al., Urol Int 2005 (Carcinoma, Transitional Cell...) : Fas ligand and TNF related apoptosis inducing ligand induction on infiltrating lymphocytes in bladder carcinoma by bacillus Calmette-Guérin treatment
Marfè et al., PloS one 2011 (Coronavirus Infections) : In addition, CCoV-II induces a remarkable increase in the expression of TNF related apoptosis inducing ligand ( TRAIL ), while we observed a slight up-regulation of FasL/Fas at 36 p.i. with a decrease of both proteins at the end of infection