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GALP — GNRH1

Text-mined interactions from Literome

Seth et al., Endocrinology 2004 : Galanin-like peptide stimulates the release of gonadotropin releasing hormone in vitro and may mediate the effects of leptin on the hypothalamo-pituitary-gonadal axis ... In addition, we show that GALP stimulates the release of GnRH from hypothalamic explants and GT1-7 cells ... We therefore investigated whether the effect of GALP on GnRH release may be mediated via a known galanin receptor ... GALP stimulated GnRH release from hypothalamic explants was attenuated ( but not abolished ) by the galanin receptor antagonist galantide ... However, GALP stimulated GnRH release from GT1-7 cells was not diminished by the coadministration of galantide ... These observations suggest that GALP may stimulate GnRH release through an indirect pathway involving a galanin receptor and via a direct action on GnRH neurons, possibly through a novel receptor
Uenoyama et al., J Neuroendocrinol 2008 (Obesity...) : These results suggest that hypothalamic GALP is likely involved in stimulating GnRH/LH release, and that the stimulatory effect of GALP on LH release is oestrogen dependent in female rats