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HMGB1 — MMP2

Text-mined interactions from Literome

Huang et al., Chin J Cancer 2004 (Pancreatic Neoplasms) : MMP-2 and MMP-9 activities were also inhibited by antisens-HMGB1 ( P < 0.01 )
García-Arnandis et al., Arthritis Res Ther 2010 (MAP Kinase Signaling System...) : In OA synoviocytes, HMGB1 alone at concentrations of 15 or 25 ng/ml did not affect the production of IL-6, IL-8, CCL2, CCL20, MMP-1 or MMP-3, but in the presence of IL-1ß, a significant potentiation of protein and mRNA expression, as well as MMP activity was observed ... In OA synoviocytes, HMGB1 alone at concentrations of 15 or 25 ng/ml did not affect the production of IL-6, IL-8, CCL2, CCL20, MMP-1 or MMP-3, but in the presence of IL-1ß, a significant potentiation of protein and mRNA expression, as well as MMP activity was observed
Limana et al., PloS one 2011 (Heart Failure...) : HMGB1 also enhanced MMP2 and MMP9 activity and decreased TIMP-3 levels
Wähämaa et al., Arthritis Res Ther 2011 (Arthritis, Rheumatoid...) : HMGB1 in complex with IL-1ß increased MMP production from both RASF and OASF
Kohno et al., J Cardiol 2012 (Aortic Aneurysm, Abdominal...) : HMGB1 blockade markedly reduced the number of macrophages and MMP-2 and MMP-9 activity in aneurysmal tissue
Wang et al., Cancer Biol Ther 2012 (Lung Neoplasms) : We observed a MyD88 dependent upregulation of matrix metalloproteinase (MMP) 2 , MMP9 and cyclin dependent kinase (CDK) 2 in 95D cells in response to HMGB1