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IKBKG — IL18
Text-mined interactions from Literome
Li et al., J Exp Med 1999
:
Accordingly, IKKbeta-deficient cells are defective in activation of
IKK and NF-kappaB in
response to either tumor necrosis factor alpha or
interleukin 1
Lamothe et al., J Biol Chem 2007
:
Reconstituting TRAF6-deficent cells with various TRAF6 mutants, we clearly demonstrate the requirement for the TRAF6 RING domain and site-specific auto-ubiquitination of TRAF6 to activate
IKK in
response to
interleukin-1
Valente et al., Cell Signal 2013
:
IL-18 induced Nox1 dependent ROS generation, TRAF3IP2 expression, and
IKK/NF-?B and JNK/AP-1 activation ... Importantly, the HMG-coA reductase inhibitor simvastatin attenuated
IL-18 induced
TRAF3IP2 induction
Valente et al., Cell Signal 2013
:
Here we demonstrate for the first time that the proinflammatory cytokine
interleukin (IL)-18 induces
TRAF3IP2 expression in primary cardiac fibroblasts ( CF ) in a Nox4/hydrogen peroxide dependent manner
O'Connell et al., J Biol Chem 1998
:
Recently, we have reported that the tumor necrosis factor and
interleukin 1 signaling pathways
activate two kinases,
IKK1 and IKK2