◀ Back to CTNNB1
CTNNB1 — MET
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
CTNNB1
→
MET
(increases, CTNNB1 Activity)
Evidence: Page 54 - "HGF/SF stimulation promotes the tyrosine phosphorylation of b-catenin, interfering with the ability of b-catenin to bind the intracellular portion of E-cadherin (Figure 6). The result is a dismantling of cell-cell adhesion complexes (105)."
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KEGG Adherens junction:
MET
→
CTNNB1
(protein-protein, inhibition)
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NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
HGF(dimer)/MET(dimer) complex (MET)
→
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
(modification, activates)
Brembeck et al., Genes Dev 2004
Evidence: mutant phenotype, other species
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
HGF(dimer)/MET(dimer) complex (MET)
→
E-cadherin/beta catenin/alpha catenin complex (CDH1-CTNNB1-CTNNA1)
(translocation, collaborate)
Kimura et al., J Biol Chem 2006
Evidence: mutant phenotype
-
NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly:
N-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH2-CTNNB1-CTNNA1-CTNND1)
→
HGF(dimer)/MET(dimer) complex (MET)
(modification, collaborate)
David et al., J Cell Sci 2008
Evidence: assay, physical interaction
-
NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met):
beta catenin (CTNNB1)
→
MET/beta catenin complex (MET-CTNNB1)
(modification, collaborate)
Monga et al., Cancer Res 2002*, Zeng et al., Exp Cell Res 2006*
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met):
beta catenin (CTNNB1)
→
HGF(dimer)/MET(dimer) complex (MET-HGF)
(modification, collaborate)
Monga et al., Cancer Res 2002*, Zeng et al., Exp Cell Res 2006*
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met):
HGF complex (HGF)
→
MET/beta catenin complex (MET-CTNNB1)
(modification, collaborate)
Monga et al., Cancer Res 2002*, Zeng et al., Exp Cell Res 2006*
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met):
MET/beta catenin complex (MET-CTNNB1)
→
HGF(dimer)/MET(dimer) complex (MET-HGF)
(modification, collaborate)
Monga et al., Cancer Res 2002*, Zeng et al., Exp Cell Res 2006*
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Stabilization and expansion of the E-cadherin adherens junction:
MET (MET)
→
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
(modification, collaborate)
Qian et al., EMBO J 2004
Evidence: assay
-
NCI Pathway Database Stabilization and expansion of the E-cadherin adherens junction:
E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1)
→
HGF/MET complex (HGF-MET)
(modification, inhibits)
Qian et al., EMBO J 2004
Evidence: assay
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Danilkovitch-Miagkova et al., Mol Cell Biol 2001
(Cell Transformation, Neoplastic) :
Activation of
beta-catenin by oncogenic RON and
MET constitutes a new pathway, which might lead to cell transformation by these and other mutant growth factor RTKs
Herynk et al., Clin Exp Metastasis 2003
(Colorectal Neoplasms) :
Activation of
c-Met in colorectal carcinoma cells
leads to constitutive association of tyrosine phosphorylated
beta-catenin
Pai et al., FASEB J 2003
(Colonic Neoplasms...) :
Here we provide evidence that PGE2 transactivates
c-Met-R ( contingent upon functional EGFR ),
increases tyrosine phosphorylation and nuclear accumulation of
beta-catenin , and induces urokinase-type plasminogen activator receptor ( uPAR ) mRNA expression
Fischer et al., J Biol Chem 2004
(Carcinoma...) :
Interestingly, stimulation of the
Met receptor by either GPCR agonists, EGF or its cognate ligand HGF,
resulted in release of Met associated
beta-catenin and in its Met dependent translocation into the nucleus, as analyzed by small interfering RNA mediated knockdown of the Met receptor