Takahashi et al., Biochem Biophys Res Commun 2008
:
Selective depletion of Nup88 by small interfering RNA ( siRNA ) inhibited NF-kappaB dependent reporter gene activation and the nuclear translocation of NF-kappaB without affecting the upstream activation pathway in NIH3T3 cells ... Overexpression of Nup88 in tumor cells may, thus be involved in the constitutive NF-kappaB activation
Ozer et al., Cancer Biol Ther 2009
(Breast Neoplasms...) :
NUP inhibited both inducible and constitutive NFkappaB activation and affected the canonical and alternative pathways