Zhang et al., J Mol Biol 2005
:
New insights into the catalytic activation of the MAPK phosphatase PAC-1 induced by its substrate MAPK ERK2 binding ... These results suggest that Arg294 and Arg295 play an important role in PAC-1 catalytic activation induced by ERK2 binding
Liu et al., J Cell Physiol 2007
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The VSMC line PAC-1 activates the MAP kinase Erk in response to the cholesterol sequestering agents methyl-beta-cyclodextrin and nystatin
Wu et al., Oncogene 2007
(Breast Neoplasms) :
Furthermore, ectopic PAC1 inhibits ERK phosphorylation and mediates cell killing
Bokemeyer et al., J Am Soc Nephrol 1997
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This study suggests a potential mechanism to regulate ERK activity through feedback inhibition by demonstrating the ERK cascade 's induction of the dual-specificity PTPases CL100, PAC1 , and B23