Gene interactions and pathways from curated databases and text-mining

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EPHB2 — RAC1

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Clerk et al., Mol Cell Biol 2001 (Cardiomegaly) : In transfection experiments, dominant negative N17Rac1 inhibited activation of ERK by endothelin 1, whereas activated V12Rac1 cooperated with c-Raf to activate ERK
Nosaka et al., Biochem Biophys Res Commun 2001 (Fibrosarcoma) : Rac is activated by tumor necrosis factor alpha and is involved in activation of Erk
Woo et al., J Biol Chem 2002 : Consistent with those findings, leukotriene B ( 4 ) Rac-dependently stimulates ERK and cytosolic phospholipase A ( 2 ) activity, and transient transfection with plasmid expressing Rac ( V12 ), a constitutively activated Rac1 mutant, also dose-dependently stimulates ERK activity
Arai et al., Oncogene 2002 : A dominant negative Rac mutant, Rac17N, also inhibited the cytokine induced activation of Erk as well as Elk-1
Woo et al., Mol Cells 2002 (MAP Kinase Signaling System) : Our results showed that LPS induced the activation of ERK and p38 MAP kinase in a Rac dependent manner, suggesting a mediatory role of Rac1 in LPS signaling to MAPKs stimulation
Eblen et al., Mol Cell Biol 2002 (MAP Kinase Signaling System) : Phosphorylation of ERK2-delta19-25 but not of wild-type ERK2 in response to Ras V12 was greatly inhibited by dominant negative Rac ... Activated forms of Rac and Cdc42 could enhance the association of wild-type ERK2 with MEK1 but not with MEK2 in serum starved adherent cells
Rul et al., Ann N Y Acad Sci 2002 (MAP Kinase Signaling System) : Here, we describe that the inhibition of Rac1 or Cdc42 signaling leads to MAPK ERK activation via a pathway involving PI(3)K, Akt, Raf, and MEK, but not Ras
Zhong et al., Blood 2003 (MAP Kinase Signaling System) : Rac and Cdc42, but not Ras or Rho, were responsible for this MAPK/ERK activation ... PAK1 ( p21 activated kinase 1 ) activation is induced by C albicans, suggesting that PAK1 may also be involved in the Rac1 activation of MAPK/ERK ... We conclude from these data that Rac/Cdc42 dependent activation of MAPK/ERK is a critical event in the immediate phagocytic response of PMNs to microbial challenge
Penzes et al., Neuron 2003 : Activation of the EphB receptor induces translocation of the Rho-GEF kalirin to synapses and activation of Rac1 and its effector PAK
Vial et al., Cancer Cell 2003 (Colonic Neoplasms...) : ERK-MAPK signaling coordinately regulates activity of Rac1 and RhoA for tumor cell motility
Shin et al., J Biol Chem 2004 : Inhibition of ERK or PAK2, the kinases upstream of p85 betaPIX in the bFGF signaling, prevents Rac1 activation, suggesting that phosphorylation of p85 betaPIX functions upstream of Rac1 activation
Hammarberg et al., Biochem Pharmacol 2004 : In addition, inhibition of Rac/Cdc42 , small GTPases of the Rho family, by clostridium toxin B, diminished p38 phosphorylation but did not affect ERK1/2
Tanaka et al., EMBO J 2004 : In cells coexpressing Tiam1 and ephrin-B1, Rac1 is activated by the extracellular stimulation of clustered soluble EphB2 receptors
Eblen et al., Mol Cell Biol 2004 (MAP Kinase Signaling System) : It was previously shown that Rac-p21 activated kinase (PAK) signaling regulated the physical association of MEK1 with ERK2 through phosphorylation sites in the proline-rich sequence (PRS) of MEK1
Gorin et al., Biochem J 2004 (Hypertrophy...) : Moreover, dominant negative Rac1 ( N17Rac1 ) blocks activation of ERK1/ERK2 in response to Ang II and AA, whereas constitutively active Rac1 resulted in an increase in ERK1/ERK2 activity
Maeda et al., Biochem Biophys Res Commun 2004 : Expression of Gab1 PI3K-m in SK-N-MC human primitive neuroectodermal tumor cells expressing wild-type RET markedly impaired Akt phosphorylation, Rac1 activation, and lamellipodia formation that were induced by GDNF whereas expression of Gab1 SHP2-m partially impaired Erk activation
Nishida et al., J Biol Chem 2005 : Dominant negative Rac inhibited angiotensin II-stimulated ROS production, JNK activation, and p38 MAPK activation but did not affect ERK activation
Qu et al., J Biochem 2005 (Diabetes Mellitus, Experimental...) : FcepsilonRI mediated tyrosine phosphorylation of Syk, Gab2, and phospholipase C-gamma1, and activation of c-Jun N-terminal kinase (JNK), extracellular signal regulated kinase ( ERK ), p38 mitogen activated protein kinase ( MAP kinase ), and inhibitor of nuclear factor kappaB kinase ( IKK ), and generation of Rac1 are unaffected in cells overexpressing the truncated Cbl-b in the lipid raft
Jin et al., Am J Physiol Gastrointest Liver Physiol 2006 (MAP Kinase Signaling System) : However, inhibition of Rac1 significantly decreased apoptosis in the presence of ERK1/2 and Akt inhibitors, similar to the effect observed with NSC-23766 alone in response to TNF-alpha
Chaturvedi et al., J Biol Chem 2007 : We investigated whether Src and Rac1 mediate deformation induced FAK and ERK phosphorylation and proliferation in human Caco-2 and rat IEC-6 intestinal epithelial cells
Slupsky et al., Am J Pathol 2007 (Leukemia, Hairy Cell) : Inhibition with toxin B showed that Rac1 plays no role in ERK activation in HCs
Tushir et al., EMBO J 2007 : Second, ARF6 induced ERK activation regulates Rac1 activation during tubule initiation through the expression of the receptor for urokinase type plasminogen activator
Bruinsma et al., Proc Natl Acad Sci U S A 2007 (MAP Kinase Signaling System) : Chimaerin and Rac regulate cell number, adherens junctions, and ERK MAP kinase signaling in the Drosophila eye
Wu et al., J Biol Chem 2007 (MAP Kinase Signaling System) : Instead, knock down of the novel oxidase Nox4 completely suppressed Tat dependent Ras and ERK activation downstream of Rac1 and RhoA
Tan et al., Biochim Biophys Acta 2008 (Carcinoma, Hepatocellular...) : The Rac1 activation by HBV replication also resulted in the phosphorylation of ERK1/2 and AKT, the downstream targets of Rac1 signaling cascade
Notcovich et al., Exp Cell Res 2010 : On the other hand, H1R induced ERK1/2 activation was inhibited by U73122 but not affected by C3 or beta2-chimaerin, suggesting that ERK1/2 activation was dependent on PLC and independent of RhoA or Rac
Kowluru et al., Diabetes 2010 : Lastly, siRNA mediated silencing of endogenous expression of ERK1/2 markedly attenuated glucose induced Rac1 activation and insulin secretion
Yuan et al., Clin Exp Metastasis 2010 (Brain Neoplasms...) : In this study, we investigated whether ERK regulates Rac1/Pak1 signaling and is critically linked to MB cell migration ... We conclude that Rac1/Pak1 signaling is critical to MB cell migration and is functionally dependent on PDGFRß/ERK activity
Déléris et al., J Biol Chem 2011 (MAP Kinase Signaling System) : We show that group I PAKs phosphorylate ERK3 and ERK4 on Ser-189 and Ser-186, respectively, both in vitro and in vivo, and that expression of activated Rac1 augments this response ... Reciprocally, silencing of PAK1/2/3 expression by RNA interference ( RNAi ) completely abolishes Rac1 induced Ser-189 phosphorylation of ERK3
Du et al., PloS one 2011 (Breast Neoplasms) : PI3K and ERK induced Rac1 activation mediates hypoxia induced HIF-1a expression in MCF-7 breast cancer cells ... Taken together, our study demonstrated that hypoxia induced HIF-1a expression involves a cascade of signaling events including ROS generation, activation of PI3K and ERK signaling, and subsequent activation of Rac1
Curtis et al., Mol Cell Neurosci 2012 (MAP Kinase Signaling System) : Rac1b regulates NT3 stimulated Mek-Erk signaling, directing marrow isolated adult multilineage inducible ( MIAMI ) cells toward an early neuronal phenotype
Yan et al., Breast Cancer Res 2012 (Breast Neoplasms) : With Rac1-specific inhibitor, dominant negative mutant Rac1 ( N17Rac1 ) and specific small interfering RNA, the effect of Rac1 on IR-induced G2/M checkpoint response and ERK1/2 activation was examined in human breast cancer cells
Eastman et al., Cell Signal 2012 : Autonomous ERK activation by uPAR requires H-Ras and Rac1
Hu et al., Cell Signal 2013 (Carcinoma, Hepatocellular...) : Inhibitor studies revealed that ERK was required for HGF induced paxillin phosphorylation at Ser178, whereas PKC and Rac-1 may suppress HGF induced phosphorylation of ERK and paxillin ( at Ser178 ) and upregulate phosphorylation of paxillin at Tyr31
Frost et al., Mol Cell Biol 1996 : Although neither activated Rac nor the PAKs stimulate ERK2 activity, overexpression of either dominant negative Rac2 or the N-terminal regulatory domain of PAK1 inhibits Ras mediated activation of ERK2, suggesting a permissive role for Rac in the control of the ERK pathway
Zohn et al., Mol Cell Biol 1998 (Cell Transformation, Neoplastic) : Fourth, Mas and Rac1 strongly activated the JNK and p38, but not ERK , mitogen activated protein kinases
Miranti et al., Curr Biol 1998 : This pathway may regulate multiple downstream events in hematopoietic cells, including Rac induced lamellipodia formation, tyrosine phosphorylation of Cbl, and activation of JNK, ERK2 and the phosphatidylinositol 3'-kinase regulated kinase Akt