Gene interactions and pathways from curated databases and text-mining

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SLPI — SMAD5

Text-mined interactions from Literome

Lv et al., Nan Fang Yi Ke Da Xue Xue Bao 2013 : Transfection of the BMSCs with Smad1 siRNA decreased the basal level of Smad1/5/8 protein expression, and also inhibited Sr-induced up-regulation of p-Smad1/5/8 and Runx2 expressions as well as Sr-induced enhancement of ALP activity and formation of mineralized nodules
Yamamoto et al., Biochem Biophys Res Commun 1997 : When Smads were transiently transfected into C2C12 cells, both Smad1 and Smad5 induced alkaline phosphatase (ALP) activity and decreased the activity of myogenin promoter/chloramphenicol acetyltransferase ( myogenin-CAT ) without BMP-2 ... On the other hand, Smad1 and Smad5 decreased myogenin-CAT activity but did not induce ALP activity in MyoD transfected NIH3T3 fibroblasts