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APC — GRAP2

Text-mined interactions from Literome

Xue et al., Arthritis Rheum 2007 (Arthritis, Rheumatoid...) : Furthermore, APC directly suppressed the production of tumor necrosis factor (TNF) and the activation of NF-kappaB and MAP kinase p38 , and inhibitors of NF-kappaB or p38 reduced the production of MMP-9, suggesting that APC inhibits MMP-9 by blocking TNF, NF-kappaB, and p38
Xue et al., J Cell Mol Med 2009 : APC dose-dependently stimulated phosphorylated ( P ) -ERK2 and inhibited P-p38
Flacke et al., Apoptosis 2009 : APC led to a transient activation of p38 and Akt kinases, but not of JNK and ERK1/2 kinases, which was accompanied by significant reduction of the apoptotic cell number, caspase-12/-3 cleavage and Bcl-xL overexpression